نتایج جستجو برای: n11
تعداد نتایج: 192 فیلتر نتایج به سال:
Sphingomonas sp. strain A4 is capable of utilizing acenaphthene as its sole carbon and energy source. To isolate the genes responsible for acenaphthene degradation, transposon mutagenesis was performed on strain A4 and four mini-Tn5-inserted mutants lacking the ability to utilize acenaphthene were isolated. In three of the four mini-Tn5 inserted mutants, the mini-Tn5s were inserted into the sam...
The naturally occurring polyamines putrescine, spermidine, and spermine are required for cell growth. Based on this requirement, several polyamine analogues that interfere with polyamine function and metabolism have been synthesized as antineoplastic agents. The symmetrically substituted N1,N12-bis(ethyl)spermine (BESpm), and unsymmetrically substituted N1-ethyl-N11-[(cyclopropyl)methyl]-4, 8-d...
A 25-year-old man suffered from recurrent, mass-like, intracerebral lesions and was diagnosed with tumefactive multiple sclerosis (MS). Both interferon β-1b and oral methotrexate (7.5 mg weekly) could not suppress frequent relapses, but he had been in remission for 8 months by the mitoxantrone treatment. At the age of 27, the patient developed a partial seizure. Brain MRI revealed a lesion in t...
We present two algorithms for maintaining the topological order of a directed acyclic graph with n vertices, under an online edge insertion sequence of m edges. Efficient algorithms for online topological ordering have many applications, including online cycle detection, which is to discover the first edge that introduces a cycle under an arbitrary sequence of edge insertions in a directed grap...
This paper presents an experiment in nsing n fnrmnl techniqne for static prngrnm nnnlyais, hnsod an abstract intarpre t.ntion, in the context of persistent progrnmming Inngnngw. The nim of thn annlysis is to dntoct npportnnities for snfe parallelism fnr trnnsnetinn nperatinn sehadnling. Tmnsnctinn apcratinns cnn he snfely intarlanved when there is no nverlnpping among their rends& nnd writ-b. A...
UNLABELLED A proangiogenic role for Jagged (JAG)-dependent activation of NOTCH signaling in the endothelium has yet to be described. Using proteins that encoded different NOTCH1 EGF-like repeats, we identified unique regions of Delta-like ligand (DLL)-class and JAG-class ligand-receptor interactions, and developed NOTCH decoys that function as ligand-specific NOTCH inhibitors. N110-24 decoy blo...
The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify brainstem regions differentially affected and resistant to the disease. Relying on these imaging findings, we then profiled gene expression levels from postmortem brainstem regio...
Chromosomal rearrangements can be triggered by recombination between distinct but related regions. Brassica napus (AACC; 2n = 38) is a recent allopolyploid species whose progenitor genomes are widely replicated. In this article, we analyze the extent to which chromosomal rearrangements originate from homeologous recombination during meiosis of haploid B. napus (n = 19) by genotyping progenies o...
BACKGROUND: Short Latency Somatosensory Evoked Potentials (SEPs) may serve to the testing of the somatosensory tract function, which is vulnerable and affected in vascular encephalopathy. The aim of the current study was to search for clinical and neuroimaging correlates of abnormal SEPs in vascular dementia (VD) patients. MATERIALS AND METHODS: The study included 14 VD patients, aged 72.93 Plu...
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