نتایج جستجو برای: n phenylthiourea

تعداد نتایج: 976631  

2002
Richard L. Doty

There have been few quantitative cross-cultural studies of taste and smell perception in humans, despite the obvious relevance of such research to scientific and commercial enterprises, and the fact that many cultures differ in their food preparation, dietary, and personal hygienic practices. The important role of the chemical senses to the species as a whole in such diverse matters as the dete...

Journal: :Journal of Investigative Dermatology 2023

Tyrosinase catalyzes the initial, rate-limiting step of melanin synthesis; oxidative conversion L-tyrosine to L-dopa followed by L-dopaquinone means oxygen molecule. possesses bicopper active center capable utilizing molecular oxygen. Metabolic rhododendrol (RD) tyrosinase causes leukoderma in a certain population consumers. Along with cytotoxic RD metabolites, reactive species (ROS) produced d...

Journal: :Biology letters 2017
Laurentia Henrieta Permita Sari Purba Kanthi Arum Widayati Kei Tsutsui Nami Suzuki-Hashido Takashi Hayakawa Sarah Nila Bambang Suryobroto Hiroo Imai

Bitterness perception in mammals is mostly directed at natural toxins that induce innate avoidance behaviours. Bitter taste is mediated by the G protein-coupled receptor TAS2R, which is located in taste cell membranes. One of the best-studied bitter taste receptors is TAS2R38, which recognizes phenylthiocarbamide (PTC). Here we investigate the sensitivities of TAS2R38 receptors to PTC in four s...

2015
Ravinder Abrol Jun Tan Hongxiang Hui William A. Goddard Stephen J. Pandol

Background: Taste receptors are G protein-coupled receptors that, besides being present in the taste buds, have also been shown to be present in the gastrointestinal (GI) system, respiratory system, and brain. However, their function at these locations is not well understood. Objective: To understand the nutrient mediated release of gut peptides like GLP-1 from enteroendocrine L-cells of the GI...

2016
Davide S. Risso Massimo Mezzavilla Luca Pagani Antonietta Robino Gabriella Morini Sergio Tofanelli Maura Carrai Daniele Campa Roberto Barale Fabio Caradonna Paolo Gasparini Donata Luiselli Stephen Wooding Dennis Drayna

The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events ...

2017
Nikita S Kasianov Irina A Belousova Sergey V Pavlushin Ivan M Dubovskiy John D Podgwaite Vyacheslav V Martemyanov Stanislav A Bakhvalov

Host innate immunity is one of the factors that determines the resistance of insects to their entomopathogens. In the research reported here we studied whether or not phenoloxidase (PO), a key enzyme in the melanogenesis component of humoral immunity of insects, plays a role in the protection of Lymantria dispar larvae from infection by L. dispar multiple nucleopolyhedrovirus. We studied two ty...

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