Carroll, Robert E., Kristina A. Matkowskyj, Subrata Chakrabarti, Thomas J. McDonald, and Richard V. Benya. Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G655– G665, 1999.—Epithelial cells lining the adult human colon do not normally express gastrin-releasing peptide (GRP) o...

Objective. The relationship between sleep quality and pain has been studied in populations with chronic pain and in nonclinical populations using experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a nonclinical sample and to explore familial (i.e., shared genetic and common family environment...

Shangraw, Robert E., and Farook Jahoor. Effect of liver disease and transplantation on urea synthesis in humans: relationship to acid-base status. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1145–G1152, 1999.—It has been suggested that hepatic urea synthesis, which consumes HCO3 , plays an important role in acid-base homeostasis. This study measured urea synthesis rate (Ra urea) dir...

Hurley, Bernard R., Harold G. Preiksaitis, and Stephen M. Sims. Characterization and regulation of Ca21dependent K1 channels in human esophageal smooth muscle. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G843– G852, 1999.—We examined the properties of K1 channels in smooth muscle cells dissociated from human esophagus using patch-clamp recording in the cell-attached configuration. Th...

Jensen, Michael D. Regional glycerol and free fatty acid metabolism before and after meal ingestion. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E863–E869, 1999.—We measured splanchnic and leg glycerol [and free fatty acid (FFA)] uptake and release in 11 healthy volunteers before and after meal ingestion to assess whether regional FFA-to-glycerol release ratios mirror systemic release ratios. ...

nétics for prepackaged emergency contraceptive pills. The application was approved, and the company began marketing the product (under the trade name Preven) in September 1998. This development presumably indicates a more open and positive policy climate for emergency contraception, and the product should lead to standardization of postcoital contraception service delivery at the clinic level. ...

Kwon, Hyeok Y., Ta-Min Chang, Kae Y. Lee, and William Y. Chey. Vagus nerve modulates secretin binding sites in the rat forestomach. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1052–G1058, 1999.—Secretin is well known for its inhibitory action on gastric motility. It has been reported that secretin in a physiological dose inhibits gastric motility through mediation by the vagal affer...

Asfaha, Samuel, Cameron J. Bell, John L. Wallace, and Wallace K. MacNaughton. Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G703–G710, 1999.—Colonic epithelial secretion is an important host defense mechanism. We examined whether a bout of colitis would produce long-lasting changes i...

Leclercq-Meyer, Viviane, Marcel M. Kadiata, and Willy J. Malaisse. Stimulation by 2-deoxy-D-glucose tetraacetates of hormonal secretion from the perfused rat pancreas. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E689– E696, 1999.—The effects of aand b-2-deoxy-D-glucose tetraacetate (1.7 and 8.5 mM) on insulin, somatostatin, and glucagon secretion from isolated rat pancreases perfused in the pr...

Wiest, Reiner, Vijay Shah, William C. Sessa, and Roberto J. Groszmann. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1043–G1051, 1999.—Chronic high blood flow and the hyperdynamic circulatory syndrome in portal hypertension are associated with endothelial constitutive nitric oxide (NO) ...