The bootstrap is a statistical technique used more and more widely in econometrics. While it is capable of yielding very reliable inference, some precautions should be taken in order to ensure this. Two “Golden Rules” are formulated that, if observed, help to obtain the best the bootstrap can offer. Bootstrapping always involves setting up a bootstrap data-generating process (DGP). The main typ...

RATIONALE Several reports suggest that antisense oligonucleotides against miR-33 might reduce cardiovascular risk in patients by accelerating the reverse cholesterol transport pathway. However, conflicting reports exist about the impact of anti-miR-33 therapy on the levels of very low-density lipoprotein-triglycerides (VLDL-TAG). OBJECTIVE We test the hypothesis that miR-33 controls hepatic V...

Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions. Although many studies have demonstrated that Siva-1 functions in the cytoplasm, a few have found that Siva-1 can relocate to the nucleus. In this study, we found that the first 33 amino acid residues of Siva-1 are required for ...

In the crystal structure of the title compound, [Pd2(C36H42N6)Cl2](ClO4)2·2C3H7NO·2CH3OH, the dinuclear Pd(II) complex cation lies on an inversion center. Each Pd(II) ion has a distorted square-planar coordination sphere, defined by three N atoms of the macrocyclic ligand and a chloride ion. The Pd(II) complex cations and the methanol mol-ecules are linked through N-H⋯O and O-H⋯O hydrogen bonds...

OBJECTIVES/HYPOTHESIS Interleukin (IL)-33 is a novel member of the IL-1 cytokine family and a ligand for the orphan IL-1 family receptor ST2. IL-33 induces T helper 2-type inflammatory responses and is considered to play a crucial role in allergic inflammatory reactions such as asthma and atopic dermatitis. However, the role of IL-33 and its receptor ST2 in chronic rhinosinusitis remains unclea...

In this paper, lead free (K0.48,Na0.52)NbO3 (KNN(48-52)) piezoelectric ceramics were made by conventional solid state sintering process. Additives of nano ZnO (n-ZnO), nano CuO (n-CuO) and nano SnO2 (n-SnO2) were used in order to decrease the sintering temperature, as well as modifying the dielectric, piezoelectric and ferroelectric propert...

Background: Cardiovascular diseases (CVD) are the most common and socially significant comorbidities main cause of premature mortality in rheumatoid arthritis (RA). Appropriate RA therapy should not only suppress activity, but also reduce CVD risk. Objectives: To evaluate risk analyze its association with use conventional patients (pts). Methods: The study included 100 pts (92 women 8 men) aged...

S. Abachi, 12 B. Abbott, 34 M. Abolins, 23 B.S. Acharya, 42 I. Adam, 10 D. L. Adams, 35 M. Adams, 15 S. Ahn, 12 H. Aihara, 20 J. Alitti, 38 G. Álvarez, 16 G. A. Alves, 8 E. Amidi, 27 N. Amos, 22 E. W. Anderson, 17 S. H. Aronson, 3 R. Astur, 40 R. E. Avery, 29 A. Baden, 21 V. Balamurali, 30 J. Balderston, 14 B. Baldin, 12 J. Bantly, 4 J. F. Bartlett, 12 K. Bazizi, 37 J. Bendich, 20 S. B. Beri, 3...