نتایج جستجو برای: n 3 pufas

تعداد نتایج: 2518232  

Journal: :Journal of the American College of Cardiology 2011
Savina Nodari Marco Triggiani Umberto Campia Alessandra Manerba Giuseppe Milesi Bruno M Cesana Mihai Gheorghiade Livio Dei Cas

OBJECTIVES This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM). BACKGROUND One hundred thirty-three patients with NICM and minimal symptoms on standard therapy were randomized to 2 g of n-3 PUFAs or placebo. LV function and functional cap...

Journal: :Journal of lipid research 2011
Damir Zadravec Petr Tvrdik Hervé Guillou Richard Haslam Tsutomu Kobayashi Johnathan A Napier Mario R Capecchi Anders Jacobsson

ELOVL2 is a member of the mammalian microsomal ELOVL fatty acid enzyme family, involved in the elongation of very long-chain fatty acids including PUFAs required for various cellular functions in mammals. Here, we used ELOVL2-ablated (Elovl2(-/-)) mice to show that the PUFAs with 24-30 carbon atoms of the ω-6 family in testis are indispensable for normal sperm formation and fertility in male mi...

2011
Yoshihiro Miyake Keiko Tanaka Satoshi Sasaki Masashi Arakawa

BACKGROUND The recent increase in the prevalence of allergic disorders might be a consequence of increased intake of n-6 polyunsaturated fatty acids (PUFAs) and reduced intake of n-3 PUFAs. The current cross-sectional study examined the association between intake levels and the prevalence of eczema and rhinoconjunctivitis in Japanese children. METHODS Subjects were 23,388 schoolchildren aged ...

2017
Matteo Manuelli Lucio Della Guardia Hellas Cena

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are believed to be important for cardiovascular health. Many investigations have been carried out in an attempt to examine the effect of n-3 PUFAs intake, in the form of supplementation or fortified foods, for the management of cardiovascular disease (CVD) and risk factors for CVD, whereas less is known about the effect on healthy individuals. The...

2014
Marília Baierle Patrícia H. Vencato Luiza Oldenburg Suelen Bordignon Murilo Zibetti Clarissa M. Trentini Marta M. M. F. Duarte Juliana C. Veit Sabrina Somacal Tatiana Emanuelli Tilman Grune Nicolle Breusing Solange C. Garcia

Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥ 60 years) were inc...

2017
Yacong Bo Xueyuan Zhang Youli Wang Jie You Han Cui Yiwei Zhu Wei Pang Wei Liu Yugang Jiang Quanjun Lu

OBJECTIVE Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack of the n-3 PUFAs intervention in the elderly with MCI in China. The aim of the present study was to investigate the effect of n-3 PUFA supplementation on cognitive function in the Chinese elderly with MCI. METHODS Eighty six MCI individuals aged 6...

Journal: :PPAR Research 2008
Iris J. Edwards Joseph T. O'Flaherty

Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents. Dietary intake of omega-3 PUFAs has been associated with a reduced risk of certain cancers in human populations and in ...

Journal: :Neuro-Signals 2009
Kuan-Pin Su

The unsatisfactory results of monoamine-based antidepressant therapy and the high occurrence of somatic symptoms and physical illness in patients with depression imply that the serotonin hypothesis is insufficient to approach the aetiology of depression. Depressive disorders with somatic presentation are the most common form of depression. Somatization, the bodily symptoms without organic expla...

2015
Shinkan Tokudome

Dear Editor-in-Chief, Recently, Fu et al (JE, 2015;25:261–74)1 conducted a metaanalysis based on prospective cohort studies and clarified the association of prostate cancer (PCa) onset with dietary intake and blood concentrations of individual omega-3 fatty acids (or n-3 polyunsaturated fatty acids [PUFAs]). However, they could not find consistent dose-response relationships between PUFA intake...

2011
Rozenn N. Lemaitre Toshiko Tanaka Weihong Tang Ani Manichaikul Millennia Foy Edmond K. Kabagambe Jennifer A. Nettleton Irena B. King Lu-Chen Weng Sayanti Bhattacharya Stefania Bandinelli Joshua C. Bis Stephen S. Rich David R. Jacobs Antonio Cherubini Barbara McKnight Shuang Liang Xiangjun Gu Kenneth Rice Cathy C. Laurie Thomas Lumley Brian L. Browning Bruce M. Psaty Yii-Der I. Chen Yechiel Friedlander Luc Djousse Jason H. Y. Wu David S. Siscovick André G. Uitterlinden Donna K. Arnett Luigi Ferrucci Myriam Fornage Michael Y. Tsai Dariush Mozaffarian Lyn M. Steffen

Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of European ancestry. Minor alleles o...

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