Nitric oxide (NO) may play an important role in regulating retinal neuronal survival. While the precise impact of NO mechanisms on retinal neurons remains to be elucidated, it has been reported that low doses of NO may have a neuroprotective effect against N-methyl-D-aspartate (NMDA)-induced retinal neurotoxicity. Dopamine has also been recognized to have neuroprotective actions. Retinal dopami...

Amaç: Acil servis (AS), ölüm vakaları konusunda benzersizdir. Bununla birlikte, genç yaş ile ilgili AS sonuçları yaygın olarak bildirilmemiştir. Bu çalışma, bir akademik AS’in nedenlerini ve hazırlayıcı faktörleri incelemeyi amaçladık. Materyal metot: Çalışma 2018-2023 tarihleri arasında, AS’e başvuran 18-45 yaşarası ardışık 256 erişkin vakasının geriye dönük kesitsel incelenmesini içermektedir...

We describe a facile synthesis of the cyapho-cyanamide salt [Na(18-crown-6)][N(CN)(CP)] from reaction [Na(18-crown-6)][PH2] (18-crown-6=1,4,7,10,13,16-hexaoxacyclooctadecane) with dimethyl N-cyanocarbonimidate, (MeO)2C=N(CN). The proceeds elimination two equivalents methanol. Careful tuning conditions allowed for isolation and characterization N-cyano(carboximidate)phosphide intermediate [HP{C(...

Application of a fluoroiodine analogue of the Togni reagent was studied in fluorocyclization reactions. In the presence of a transition-metal catalyst the applied fluoroiodine reagent can be used for aminofluorination, oxyfluorination, and carbofluorination reactions. The described procedure has a very broad synthetic scope for preparation of functionalized hetero- and isocyclic compounds havin...

Methods for labeling the glutamate channel blocking agent MK-801 with iodine-125 (125I) and fluorine-18 (18F) are described. Radioiodine was incorporated in the 1- or 3-positions of the aromatic ring of (+/-)MK-801 by solid-state halogen exchange techniques. Attachment of the [18F]fluoromethyl group to the bridgehead methyl position was achieved by reaction of [18F]fluoride with the triflamide ...