objectives: the aim of this study was to investigate the effects of gender on plasma myostatin at rest and in response to acute resistance exercise in elderly men and women. methods & materials: 12 healthy older men (age=69±1.23 and bmi=23±0.3 kg/m2) and 12 healthy older women (age=68±2.14 and bmi=23±0.4 kg/m2) volunteered for participation in this study. 72hours after the determination of musc...

BACKGROUND Joint inflammation is a common clinical problem in patients treated by physical therapists. The hypothesis of this study is that joint inflammation induces molecular and structural changes in the soleus muscle, which is composed mainly of slow-twitch muscle fibers. OBJECTIVE To study the effect of tibiotarsal joint inflammation on muscle fiber cross-sectional area (CSA), gene expre...

Calpains play a major role in post mortem tenderization and calpastatin is the endogenous inhibitor of calpain proteases and regulates the rate and extent of post mortem tenderization. Myostatin is an inhibitor of skeletal muscle growth and a mutation in the gene coding region leads to increased muscling. Therefore, they are considered as candidate genes for meat and growth traits. Blood sample...

Myostatin is a highly conserved negative regulator of skeletal muscle growth. Loss of functional myostatin in cattle, mice, sheep, dogs, and humans results in increased muscle mass. The molecular mechanisms responsible for this increase in muscle growth are not fully understood. Previously, we have reported that phenylephrine-induced cardiac muscle growth and Akt activation are enhanced in myos...

Myostatin is a member of the TGF-beta superfamily that is essential for proper regulation of skeletal muscle growth. As do other TGF-beta superfamily members, myostatin signals into the cell via a receptor complex that consists of two distinct transmembrane proteins, known as the type I and type II receptors. Vertebrates have seven distinct type I receptors, each of which can mix and match with...

Background: Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-offunction mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding the mechanisms underpinning muscular hypertrophy. In order to identify individ...

Myostatin is an extracellular negative regulator of muscle growth with an important role in bovine muscular hypertrophy. It belongs to the transforming growth factor beta (TGFbeta) superfamily, and has structural and functional characteristics similar to those of its other, members. Based on these characteristics, we designed three gene constructs in order to create a series of dominant negativ...

Introduction: Myostatin regulates skeletal muscle mass and adipogenesis, but serum response to continuous and discontinuous exercises training it has not been studied in menopause and menstrual groups of women. The purpose of this study was to investigate the serum response of myostatin, insulin and glucose to use four different aerobic exercises training in menopause and menstrual groups of wo...

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous studies in the mdx mouse model of muscular dystrophy demonstrate that inhibiting myostatin attenuates several features of dystrophic muscle. These findings have encouraged the development of human therapies to block my...