Objective: We describe a rare case of inflammatory myofibroblastic tumour of the trachea in a 47 years old female with paratracheal lymph nodes infiltration and mediastinal extension, who presented with progressive difficulty in breathing. (Rawal Med J 2009;34:115-116).

purpose: to verify the myofibroblastic origin of spindle cells by immunohistochemistry in idiopathic inflammatory pseudotumor (ipt) of the orbit. methods: we reviewed a series of 32 orbital ipts for expression smooth muscle actin (sma), vimentin, desmin and anaplastic lymphokinase (alk). results: the study was performed on histologic samples of 33 patients with a diagnosis of orbital ipt. the l...

Inflammatory myofibroblastic tumors (IMTs), also known as inflammatory pseudotumors and inflammatory fibrosarcomas, are uncommon mesenchymal tumors composed of myofibroblastic spindle cells admixed with lymphocytes, plasma cells and eosinophils. Once thought to be reactive, these lesions are now considered to be neoplastic. These tumors can occur throughout the body, most commonly in the lung, ...

BACKGROUND Inflammatory myofibroblastic tumor (IMT) is a neoplasm of unknown etiology occurring at various sites. By definition, it is composed of spindle cells (myofibroblasts) with variable inflammatory component, hence the name is IMT. CASE PRESENTATION The present case is of a 46 years old woman presented with a history of flank pain, abdominal mass and intermittent hematuria for last 6 m...

A 28-year-old woman was referred to our hospital because of abdominal pain, weight loss and a palpable intra-abdominal mass. A CT scan revealed a tumor with a diameter of 7 cm with sharp margins, intra-tumoral fatty components and enhancing soft tissue. After initial workup, which suggested an inflammatory myofibroblastic tumor (IMT), she underwent laparotomy with complete resection. Pathologic...

BACKGROUND Inflammatory myofibroblastic tumours (IMFTs) are rare tumours characterised by nosologic, histogenetic and aetiopathogenetic controversy and variable clinicopathological features. We report our experience with intestinal-IMFTs (I-IMFTs) that have been reported mainly as single case reports to date. METHODS Five patients with I-IMFTs, identified between 2005 and 2008, formed the stu...

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic tissue stiffening is a feature of fibrotic disease, we hypothesized that mechanical properties of...