نتایج جستجو برای: myocytes

تعداد نتایج: 47386  

2016
Manal M. A. Smail Muhammad A. Qureshi Anatoliy Shmygol Murat Oz Jaipaul Singh Vadym Sydorenko Alya Arabi Frank C. Howarth Lina Al Kury

In the heart, the left ventricle pumps blood at higher pressure than the right ventricle. Within the left ventricle, the electromechanical properties of ventricular cardiac myocytes vary transmurally and this may be related to the gradients of stress and strain experienced in vivo across the ventricular wall. Diabetes is also associated with alterations in hemodynamic function. The aim of this ...

2008
Katherine A. Sheehan Yunbo Ke Beata M. Wolska John Solaro

Sheehan KA, Ke Y, Wolska BM, Solaro RJ. Expression of active p21-activated kinase-1 induces Ca -flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol 296: C47–C58, 2009. First published October 15, 2008; doi:10.1152/ajpcell.00012.2008.—p21-Activated kinase-1 (Pak1) is a serine-threonine kinase that associates with and activates protein ...

Journal: :Journal of the American College of Cardiology 1998
H Baumgartner G Porenta Y K Lau M Wutte U Klaar M Mehrabi R J Siegel J Czernin G Laufer H Sochor H Schelbert M C Fishbein G Maurer

OBJECTIVES We examined the relationship among viability assessment by dobutamine echocardiography (DE), positron emission tomography (PET) and thallium-201 single-photon emission computed tomography (TI-SPECT) to the degree of fibrosis. BACKGROUND DE, PET and TI-SPECT have been shown to be sensitive in identifying viability of asynergic myocardium. However, PET and TI-SPECT indicated viabilit...

2005
Gary A. Gintant Da-Wei Liu

Reports have suggested that the fast inward sodium current (INa) in cardiac tissues may be modulated by fl-adrenergic stimulation and that such modulation may affect conduction in the setting of myocardial ischemia and infarction. However, many of these studies have used dissociated myocytes or broken cell preparations, whose responses need not necessarily reflect those of syncytial preparation...

2005
Holly A. Shiels Ed White

Shiels, Holly A., and Ed White. Temporal and spatial properties of cellular Ca flux in trout ventricular myocytes. Am J Physiol Regul Integr Comp Physiol 288: R1756–R1766, 2005. First published January 13, 2005; doi:10.1152/ajpregu.00510.2004.—Confocal microscopy was used to investigate the temporal and spatial properties of Ca transients and Ca sparks in ventricular myocytes of the rainbow tro...

Journal: :Cardiovascular research 2004
Zoe Anne McCrossan Rudolf Billeter Ed White

OBJECTIVE Some hypertrophic stimuli provoke responses from myocytes that vary across the thickness of the left ventricular wall. The Spontaneously Hypertensive Rat (SHR) is a well-established genetic model of hypertension and whole heart hypertrophy. Details of transmural responses to hypertension in the SHR are few, but are needed if the properties of this model are to be fully understood. We ...

2002
XUE-QIAN ZHANG JIANLIANG SONG LOIS L. CARL WEIXING SHI ANWER QURESHI QIANG TIAN JOSEPH Y. CHEUNG

Zhang, Xue-Qian, Jianliang Song, Lois L. Carl, Weixing Shi, Anwer Qureshi, Qiang Tian, and Joseph Y. Cheung. Effects of sprint training on contractility and [Ca2 ]i transients in adult rat myocytes. J Appl Physiol 93: 1310–1317, 2002. First published July 5, 2002; 10.1152/ japplphysiol.01071.2001.—The effects of 6–8 wk of highintensity sprint training (HIST) on rat myocyte contractility and int...

Journal: :Circulation research 2017
Di Lang Daisuke Sato Yanyan Jiang Kenneth S Ginsburg Crystal M Ripplinger Donald M Bers

RATIONALE Intercellular uncoupling and Ca2+ (Ca) mishandling can initiate triggered ventricular arrhythmias. Spontaneous Ca release activates inward current which depolarizes membrane potential (Vm) and can trigger action potentials in isolated myocytes. However, cell-cell coupling in intact hearts limits local depolarization and may protect hearts from this arrhythmogenic mechanism. Traditiona...

2018
Matthew E. L. Hardy Eleftheria Pervolaraki Olivier Bernus Ed White

We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible for negative mechanical restitution in these myocytes. PAH and RV failure were provoked in male Wistar rats by a single injection of monocrotaline (MCT) an...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
Sampsa Pikkarainen Heikki Tokola Risto Kerkelä Mika Ilves Markus Mäkinen Hans-Dieter Orzechowski Martin Paul Olli Vuolteenaho Heikki Ruskoaho

Mechanical stretch and para- and/or autocrine factors, including endothelin-1, induce hypertrophy of cardiac myocytes and proliferation of fibroblasts. To investigate the effect of mechanical load on endothelin-1 production and endothelin system gene expression in neonatal rat ventricular myocytes and fibroblasts, we exposed cells to cyclic mechanical stretch in vitro (0.5 Hz, 10-25% elongation...

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