نتایج جستجو برای: myocardium

تعداد نتایج: 31863  

2012
James W Goldfarb Wenguo Zhao Jing Han

We observed significantly different curve shapes in healed chronic myocardial infarction when compared with normal myocardium and found that gadolinium kinetics was more accurately modeled (greater R2) with a 3C model rather than a 2C model. 2C Modeling of fibrotic and normal myocardium showed both a significant difference between the transport into the tissue and extracellular volumes while 3C...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
J Chiaka Ejike Lorilee S L Arakaki Daniel A Beard Wayne A Ciesielski Eric O Feigl Kenneth A Schenkman

Previous work from this laboratory using near-infrared optical spectroscopy of myoglobin has shown that approximately 20% of the myocardium is hypoxic in buffer-perfused hearts that are perfused with fully oxygenated buffer at 37 degrees C. The present study was undertaken to determine cardiac myoglobin saturation in buffer-perfused hearts when cardiac contractility was increased with epinephri...

2012
Grazia Ammirabile Alessandra Tessari Viviana Pignataro Dorota Szumska Fabio Sutera Sardo Jiri Benes Mariangela Balistreri Shoumo Bhattacharya David Sedmera Marina Campione

AIMS The sinus venous myocardium, comprising the sinoatrial node (SAN) and sinus horns (SH), is a region subject to congenital malformations and cardiac arrhythmias. It differentiates from symmetric bilateral mesenchymal precursors, but morphological, molecular, and functional left/right differences are progressively established through development. The role of the laterality gene Pitx2 in this...

Journal: :Circulation 2000
R J Hajjar R H Schwinger U Schmidt C S Kim D Lebeche A A Doye J K Gwathmey

BACKGROUND We investigated whether decreased myofilament calcium contractile activation may, in part, contribute to heart failure. METHODS AND RESULTS Calcium concentration required for 50% activation and Hill coefficient for fibers from nonfailing and failing human hearts at pH 7.1 were not different. Maximum calcium-activated force (F(max)) was also not different. However, at pH 6.8 and 6.9...

Journal: :The Journal of Cell Biology 2003
William Schubert Xiao Yong Yang Teddy T.C. Yang Stephen M. Factor Michael P. Lisanti Jeffery D. Molkentin Mercedes Rincón Chi-Wing Chow

Nuclear factor of activated T cell (NFAT) is a ubiquitous regulator involved in multiple biological processes. Here, we demonstrate that NFAT is temporally required in the developing atrial myocardium between embryonic day 14 and P0 (birth). Inhibition of NFAT activity by conditional expression of dominant-negative NFAT causes thinning of the atrial myocardium. The thin myocardium exhibits seve...

Journal: :Radiologic Clinics of North America 2015

Journal: :The Journal of Thoracic and Cardiovascular Surgery 1988

Journal: :Proceedings of the Royal Society of Medicine 1913

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