Normal heart development requires appropriate levels of retinoic acid (RA) signaling. RA levels in embryos are dampened by Cyp26 enzymes, which metabolize RA into easily degraded derivatives. Loss of Cyp26 function in humans is associated with numerous developmental syndromes that include cardiovascular defects. Although previous studies have shown that Cyp26-deficient vertebrate models also ha...

To investigate the protective effects, and the mechanisms involved, of an extract of the medicinal herb radix paeoniae rubra (PE) on cardiovascular disease, acute myocardial infarction (AMI) was induced by ligation of the left coronary artery in Sprague Dawley rats. Animals were randomly divided into six groups: control, sham-operated, AMI, AMI+PE low dose, AMI+PE high dose, and AMI+positive co...

Corona Virus Disease 2019 (COVID-19) is an infectious disease that has been designated as a worldwide pandemic. Symptoms of Covid-19 are not only respiratory symptoms but also extrapulmonary symptoms, including the discovery impaired liver function in form increased transaminase enzymes. Therefore, this study was conducted to see correlation enzymes with prognosis COVID-19 patients treated Inte...

Objective(s) Several studies have reported improved response of exercised hearts to myocardial infarction (MI). This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardi...

Objectives: The main objective of the study is to find comparison CKMB, Lactate levels and ejection fraction with warm cold cardioplegia on first post OP day in elective CABG cases. Material methods: This cross sectional was conducted Armed forces institute cardiology AFIC /NIHD Rawalpindi during 1st October 2022 30th November 2022. Data collected permission ethical committee hospital. variable...

This study investigated the onset of age-related changes in the myocardial antioxidant enzymes and apoptosis and the vulnerability of the myocardium to oxidative stress following exercise training. Few studies have investigated the influence of the most prevalent life-prolonging strategy physical exercise, on the age increment alterations in the myocardial antioxidant enzymes and apoptosis at m...

doxorubicin (dox) induces oxidative stress leading to cardiovascular abnormalities. green tea extract (gte) is reported to possess antioxidant activity mainly by means of its polyphenolic constituent, catechins. our study was aimed to find out the effect of gte (100 mg/kg / day p.o. for 28 days) on dox induced (3 mg/kg, ip on days 1, 7, 14, 21, 28) cardiovascular abnormalities in rat heart. dox...

Elevated plasma levels of the biomarker soluble urokinase plasminogen activator receptor (suPAR) are prognostic adverse outcomes in cardiovascular disease (CVD). This novel inflammatory protein has five known N-linked glycosylation sites, but contribution to progression is unknown. study aimed assess impact on suPAR measurements. Bio-banked samples from healthy volunteers and patients with CVD ...