thickening after brief coronary occlusions. Am J Physiol 234: H663-H659 Hoffman JIE (1978) Determinants and prediction of transmural myocardial perfusion. Circulation 58: 381-391 Kirk ES, Honig CR (1964) An experimental and theoretical analysis of myocardial tissue pressure. Am J Physiol 207: 361367 Klassen GA, L'Abbate A, Sestier F, Mildenberger RR (1977) The determinants of regional myocardia...

thickening after brief coronary occlusions. Am J Physiol 234: H663-H659 Hoffman JIE (1978) Determinants and prediction of transmural myocardial perfusion. Circulation 58: 381-391 Kirk ES, Honig CR (1964) An experimental and theoretical analysis of myocardial tissue pressure. Am J Physiol 207: 361367 Klassen GA, L'Abbate A, Sestier F, Mildenberger RR (1977) The determinants of regional myocardia...

Obesity has been shown to impair myocardial performance. Some factors have been suggested as responsible for possible cardiac abnormalities in models of obesity, among them beta-adrenergic (βA) system, an important mechanism of regulation of myocardial contraction and relaxation. The objective of present study was to evaluate the involvement of βA system components in myocardial dysfunction ind...

Intracranial pressure was increased in 59 rats by inflating a subdural balloon to a total mass volume of 0.3 ml. The increase in intracranial pressure ranged from 75 to greater than 500 mm Hg. With few exceptions, mean arterial pressure increased to as high as 227 mm Hg during the increase in intracranial pressure. Significant increases in plasma catecholamines, major electrocardiographic chang...

• The strength of myocardial contraction is influenced directly and strongly by the intervals separating individual beats. The large number of studies on this phenomenon during the 95 years since its original recognition have recently been reviewed. Interval-dependent changes in the strength and time course of contraction result both from alterations in the duration of the active state and from...

we investigated contraction to noradrenaline (na) and kc1 and sensitivity of na at the level of larger vessels (thoracic aorta and vena cava; left renal artery and left renal vein; lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in w...

Background Arrhythmias are a significant healthcare burden and an estimated 400,000 people die annually due to arrhythmia related complications. While pathological electrical activity can be observed at the endocardial surface during electrophysiology treatment, high spatial resolution non-invasive methods are needed to resolve aberrant contraction and establish correspondence with regional myo...

Yang, Zhao-Kang, Nick J. Draper, and Ajay M. Shah. Ca21-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H623–H632, 1999.—Endothelial cells release agents that influence cardiac contraction. We recently reported that cultured hypoxic endothelial cells release an unidentified factor(s) that inhibits myocar...

Coronary artery thrombosis, due either fissuring or erosion of atherosclerotic plaque, is the usual cause of acute myocardial infarction (1) and results in a progressive increase of the infarct size with a wavefront transmural extension from the endocardium towards the epicardium (2,3). Although thrombolysis and reperfusion can occur spontaneously, thrombotic coronary artery occlusion usually p...