PURPOSE This was a prospective single-arm study to assess the efficacy and safety of intradetrusor injections of onabotulinum toxin-A in children with urinary incontinence associated with neurogenic detrusor overactivity due to myelomeningocele. All patients had failed the first-line treatment of a combination of oral antimuscarinics and intermittent catheterization. MATERIALS AND METHODS The...

OBJECTIVE Although fetal magnetic resonance imaging (MRI) is being increasingly used to evaluate sonographically suspected abnormalities, its utility in the evaluation of the spinal canal is not well studied. Because it is not susceptible to the limitations of fetal position, oligohydramnios, and shadowing from bony structures, we hypothesize that fetal MRI is better suited to assess the conten...

Myelomeningocele (MM) is the most severe form of lumbosacral open neural tube defect (NTD) compatible with survival and it results in various degrees of disability. Approximately 4 in 10,000 live births are affected in the United States (US). Mexican Americans, the fastest growing ethnic population in the US, have the highest prevalence rate for NTDs follows by Caucasian Americans. Occurrence o...