CLINICAL CASE A 69-year-old man with a history of acute myeloblastic leukemia-M1 presented with bilateral conjunctival injection. Ophthalmological examination revealed lesions located at the upper tarsal conjunctiva of the right eye and lower tarsal conjunctiva of both eyes. Histological and immunohistochemical studies confirmed conjunctival myeloid sarcoma. The patient died due to multiorgan f...

The yearly incidence of the acute myeloblastic leukaemias (AMLs) in European adults is 5–8 cases per 100 000 individuals, and in myelodysplastic syndromes (MDSs) 4–5 new cases/100 000 are expected yearly. In individuals >60 years incidences of both AMLs and MDSs increase significantly, reaching 40–60 new cases of MDS per 100 000/year. Yearly mortality figures are 4–6 cases per 100 000 in AMLs a...

Unequivocal lymphoblastic leukaemia in a 4-year-old boy was followed 3 years later by equally unequivocal myeloblastic leukaemia in his 20-year-old brother. The boy achieved complete remission and remains well more than 6 years later whereas his brother failed to respond to treatment and died after 5 months. The parents and 3 remaining siblings showed no recognized features suggesting a constit...

background: the wilm’s tumor gene 1 (wt1) encodes a zinc finger transcription factor that is inactivated in a subset of wilm’s tumors. it plays a crucial role in growth, proliferation and development of some embryonic and adult organs. wt1 is expressed as a tumor associated antigen (taa) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...

Avian myeloblastosis virus produced in vitro by myeloblastic cells in suspension was labeled with 32P and 14Camino acids. After partial purification of the virus, and pronase digestion, an RNA was extracted by phenol into the aqueous phase. Glycerol gradient centrifugation showed that the 32P-labeled RNA con tained 2 distinct components: a high molecular weight fraction sedimenting at about 67 ...

Herein we present a neutropenic 16-year-old female with acute myeloblastic leukemia that developed recurrentgeneralized seizures while receiving antimicrobial therapy (including oseltamivir) due to pneumonia, bacteremiaof Klebsiella pneumoniae, and H1N1 infection. The patient's seizures were controlled using assisted ventilation.Electroencephalography showed that the patient had encephalopathy....

AMONG sixteen cases of acute leukaemia with orbital leukaemic infiltration in children, there were six myeloblastic, six monoblastic, two lymphoblastic (Mortada 1962, 1963, 1964a), one undifferentiated stem-cell, and one aleukaemic leukaemia. The following case of lymphoblastic aleukaemic leukaemia is described because bilateral proptosis in this condition has been only rarely reported, and bec...