JASMONATE ZIM-DOMAIN (JAZ) proteins are primary transcriptional repressors in the jasmonate (JA) signal-ing pathway that regulate a broad range of JA-dependent responses. A mechanistic mode of action is well established , but what are the biological roles of individual JAZs, and how do they contribute to the specification of JA signaling outputs? Two recent articles in Journal of Experimental B...

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...