BACKGROUND The clinical outcome of dogs affected by degenerative mitral valve disease (MVD) without overt clinical signs is still poorly defined, and criteria for identification of animals that are at a higher risk of early decompensation have not yet been determined. HYPOTHESIS N-terminal pro-B-type natriuretic peptide plasma concentration (NT-proBNP) is correlated with mitral regurgitation ...

Tumor angiogenesis is known to be regulated by growth factors secreted by host and tumor cells. Despite the importance of tumor vasculature and angiogenic heterogeneity in solid tumors, few studies have compared the vasculature in different regions of human cancer. Blood vessels from different regions of carcinomas might have morphofunctional implications in tumor angiogenesis. In the present s...

Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using h...

BACKGROUND Microvascular decompression (MVD) and rhizotomy are all selected for treating vagoglossopharyngeal neuralgia (VGPN). Nonetheless, controversies still exist about their curative effect on VGPN. Here we evaluate the effectiveness of MVD together with rhizotomy of the glossopharyngeal nerve for the treatment of VGPN. METHODS This study was carried out on 21 patients who were diagnosed...

Recent studies revealed that CD105 is intensively expressed in tumor vasculature, and may be an important prognostic indicator for the outcome in a number of malignancies. The aim of our study was to evaluate the CD105 expression and microvessel density in oral squamous cell carcinoma (OSCC). Nineteen surgical specimens with OSCC were immunohistochemical analyzed with CD105 (Endoglin). We deter...

The Micro-Vertex Detector (MVD) of the CBM experiment will be located close to the collision point and exposed to very high track densities from heavy ion collisions produced at high interaction rates. The design of the MVD requires a detailed knowledge of the detector occupancies and the corresponding data rates, which were simulated in this work. The first step of the study was to determine t...

OBJECTIVES We sought to identify the expression of CD68-tumor-associated macrophages (TAMs) and CD34-microvascular density (MVD) in laryngeal squamous cell carcinoma (LSCC), to study the relationship with clinical pathological parameters and to determine whether their expression is predictive of disease. METHODS Pathologically confirmed 45 LSCC tissue and 20 peritumoral non-tumor tissue were ...

BACKGROUND Among the patients with bladder cancer, a group is still at risk of disease recurrence, progression, and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial carcinoma and is a potential therapeutic target. OBJECTIVES To quantify tumor angiogenesis in bladder cancer and determine whether it correlates with tumo...

INTRODUCTION : Angiogenesis is of key importance in the process of tumor progression in a number of tumor types including breast cancer . In my study I have used anti CD34 antibody to assess intratumoral microvessel density (MVD) in 96 cases to estimate neo-angiogenesis and compared it in various prognostic groups . OBJECTIVES OF STUDY :To study MVD in malignant breast lumps by immunohistochemi...