We describe the use of pattern recognition and multivariate regression in the assessment of complex mixtures by correlating chemical fingerprints to the mutagenicity of the mixtures. Mixtures were 20 organic extracts of exhaust particles, each containing 102-170 individual compounds such as polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs, oxy-PAHs, and saturated hydrocarbons. Mixtures were ...

In globe, Pyllanthus niruri is a well-established medicinal herb studied by many researchers, grown widely in many parts of West Bengal. The present study was aimed to predict the acute toxicity as LC50 in Daphnia magna and Pimephales promelas and rat oral LD50 value as well as Ames mutagenicity by using QSAR modeling software, T.E.S.T. (Toxicity Estimation Software Tool) for commonly found phy...

ŠMERÁK P., POLÍVKOVÁ Z., ŠESTÁKOVÁ H., ŠTĚTINA R., BÁRTA I., LANGOVÁ M., TUREK B., BÁRTOVÁ J. (2006): Antimutagenic effect of curcumin and its effect on the immune response in mice. Czech J. Food Sci., 24: 72–83. A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most e...

Sediments in estuaries are of important environmental concern because they may act as pollution sinks and sources to the overlying water body. These sediments can be accumulated by benthic organisms. This study assessed the mutagenic potential of sediment extracts from the Yangtze River estuary by using the Ames fluctuation assay with the Salmonella typhimurium his (-) strain TA98 (frameshift m...

Within an EU-funded research project, 281 textile dye products in use at nine textile finishing companies from eight European countries were assessed for potential mutagenic properties. Most of the dyes belonged to the so-called existing substances. Data sources considered were data published in the literature, unpublished industrial data provided by dye producing companies, and laboratory test...

The mutagenicity of 12 cycloaliphatic epoxides was investigated using the Ames Salmonella assay without the addition of liver homogenate fractions. Base-pair substitution mutagenic activity was detected for 8 members of this series of compounds, confirming our laboratory's previous observations of weak mutagenic response at high dose levels for cis-1,2-disubstituted epoxides. While mutagenicity...

With the growing number of new exhaust after-treatment systems, fuels and fuel additives for internal combustion engines, efficient and reliable methods for detecting exhaust genotoxicity and mutagenicity are needed to avoid the widespread application of technologies with undesirable effects toward public health. In a commonly used approach, organic extracts of particulates rather than complete...