Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran–Iraq war. He developed skin lesions ...

OBJECTIVE To evaluate bronchial challenges using three different stimuli as screening tools for bronchial hyper-responsiveness in sulfur mustard gas-induced asthma. DESIGN Randomized, cross-over clinical study. SETTING University hospital. PATIENTS Eighteen veterans with mustard gas-induced asthma and 18 normal veterans as the control group. INTERVENTION Pulmonary function tests and inh...

Background: Sulfur mustard gas is a chemical agent that has been used in many wars, especially in Iran-Iraq war. This chemical agent affects many organs including lungs, eyes and skin, causing numerous acute and chronic lesions including erythema and hyperpigmentation, respectively. This study was conducted to evaluate erythema and melanin in subjects with a history of exposure to sulfur ...

gas is not destroyed but only dissolved, and care must be taken not to spread the contamination by allowing the solvent to run. lThorough washing with soap and water will complete the treatment. 3. T7horough washing with soap and water.-If some time has elapsed after contamination, the washing treatment should still be carried out at the first opportunity with the hopes of mitigating the degree...

AIM Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used biochemical analyses to investigate the effect of NM gas administered through the dermal and respiratory routes, on the brain cortex of rats and also tried to show whether the antioxidant Proanthocyanidi...

The exposure of two Iranian victims of the Iran-Iraq conflict (1980-1988) to sulfur mustard was established by immunochemical and mass spectrometric analysis of blood samples taken 22 and 26 days after alleged exposure. One victim suffered from skin injuries compatible with sulfur mustard intoxication but did not have lung injuries; the symptoms of the other victim were only vaguely compatible ...

The systemic use of thiol-containing uroepithelial protecting agents, e.g., N-acetylcysteine (NAC) or mesna, in conjunction with the alkylating agent cyclophosphamide is predicated on the assumption that the toxic metabolic by-products will be consumed by thiol without diminishing the cytotoxicity of the active alkylating intermediate, phosphoramide mustard. Studies in murine tumor systems have...

Many works were made on the biological application of mustard gas and nitrogen mustard. The mechanism of the biological action of mustards , however, remains largely unknown, and many experimental results have been accumulated to, suggest its mode of actions(1) , among which much attention has been called to the analogy of its action to those of X-ray irradiation or of hydrogen peroxide(2). Her...