Background Night-time calf muscle cramps are highly prevalent and are associated with reduced quality of sleep and healthrelated quality of life [1]. The underlying mechanism is poorly understood and no treatment has shown consistent efficacy or safety. The aim of this study was to identify factors associated with night-time calf cramping in adults to explore potential underlying mechanisms and...

Background Leg muscle cramps have been identified as the strongest independent predictor of worse quality of life in Australian children with Charcot-Marie-Tooth disease Type 1A (CMT1A) [1]. There is no accepted treatment for cramp in children with CMT and the cause of cramp is not well understood. Potential therapeutic targets should be carefully identified to direct clinical trials of interve...

We report the first of two recent deaths from Irukandji syndrome. A 58-year-old male tourist was stung on the face and chest by an unidentified jellyfish in shallow water off the Whitsunday Islands, Queensland. He developed muscle cramps, sweating, anxiety, nausea and hypertension, and died 30 hours later from intracerebral haemorrhage.

BACKGROUND Intra-dialytic morbid events (IDME) such as intra-dialytic hypotension (IDH) and muscle cramps frequently complicate haemodialysis (HD). Cardiac dysfunction is highly prevalent in HD patients. We investigated the relationship between proto-dialytic (i.e. early intra-dialytic) cardiac function and IDME in HD patients. METHODS Heart rate, beat-to-beat blood pressure (BP) and cardiac ...

Introduction: Magnesium is an uncommon electrolyte in a sports hydration drink despite the fact that many endurance athletes suffer from muscle cramps and soreness during marathon events. We tested if optimal amount of elemental magnesium (100 mg/serving) mix can reduce incidence severity cramps. Methods: The open survey was conducted using questionnaire about participating completed after fini...

We present a 16-year-old girl with a unique clinical phenotype characterized by rapidly progressive exercise intolerance, transient exertional weakness, and progressive muscle cramps involving all limbs and bulbar muscles, following a first myoglobinuric episode at age 15 years, arising from homozygosity for a novel missense mutation (c.281G>C) in PYGM.