We have sequenced the conjugative plasmid pPR9, which carries the ileS2 gene, which had contributed to the dissemination of high-level mupirocin resistance at our institution. The plasmid backbone shows extensive genetic conservation with plasmids belonging to the pSK41/pGO1 family, but comparative analyses have revealed key differences that provide important insights into the evolution of thes...

To determine appropriate mupirocin susceptibility testing interpretive criteria, 177 staphylococci were tested by agar dilution, disk diffusion, and E test. E test was found to be a reliable method for determining susceptibility of staphylococci to mupirocin. The agar dilution and disk diffusion results were plotted on a scattergram, and error rates were calculated. No errors were found with su...

abstract        background and objective: staphylococcus aureus is the most common and important infectious agent. this bacterium can enter the bloodstream and cause some complications in the intensive care unit (icu).this organism can frequently be found in the nose and transmitted by the carriers. this study aimed to determine the efficiency of eradicating s. aureus from the nose of icu perso...

OBJECTIVES/HYPOTHESIS To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection. STUDY DESIGN Prospective open-label pilot study. METHODS Patients with surgically recalcitrant CRS who had positive nasendoscopically guided cultures for Staphylococcus aureus were trea...

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amin...

The objective of the present study was to investigate the antibiotic susceptibility including mupirocin among Staphylococcus. epidermidis isolated from prosthetic joint infections (PJIs) (n=183) and nasal isolates (n=75) from patients intended to undergo prosthetic joint replacements. Susceptibility to mupirocin (used for eradication of nasal carriership of Staphylococcus aureus) was investigat...

nasal mupirocin is found to eradicate effectively methicillin-resistant staphylococcus aureus (mrsa) from colonized patients, but there are concerns about resistant strains. the aim of this study was to detect the mupirocin resistance and nasal carriage of methicillin resistant s. aureus among healthcare workers (hcws) at the university hospitals of tehran.totally 270 nasal swabs were collected...

Chronic hemodialysis (CHD) patients are vulnerable to infections, including infections by methicillin-resistant staphylococci (MRS) because they are repeatedly exposed to the hospital environment and often receive prolonged courses of antibiotics, besides being immunocompromised1. Nasal carriage of MRS in hospital personnel also adds to the colonization pressure in healthcare facilities, acting...

OBJECTIVES The objectives of this study were to determine the susceptibility of Methicillin Resistant Staphylococcus aureus (MRSA) isolates to Mupirocin and other antimicrobial agents and to record the prevalence and distribution of this organism at the University Hospital of the West Indies (UHWI). METHODS MRSA isolates collected between January 1, 2008 and December 31, 2008, were tested for...