Mumps virus is a common infectious agent of humans, causing parotitis, meningitis, encephalitis, and orchitis. Like other paramyxoviruses in the genus Rubulavirus, mumps virus catalyzes the proteasomal degradation of cellular STAT1 protein, a means for escaping antiviral responses initiated by alpha/beta and gamma interferons. We demonstrate that mumps virus also eliminates cellular STAT3, a pr...

IKEDA, S., CHIBA, S., CHIBA, Y., NAKAO, T. and Fuuui, S. Epidemiological, Clinical and Serological Studies on Epidemic of Mumps in an Infant Nursery. Tohoku J. exp. Med., 1971, 105 (4), 327-337 •\ Epidemiological, clinical and serological studies on the epidemic mumps were carried out in 47 infants in Central Babies Home, Sapporo. Furthermore by utilizing fluorescent antibody tests the influenc...

Despite the extensive use of Mumps virus vaccines for almost forty years, there is still a paucity of knowledge concerning the Host-Pathogen Interaction. This paper reviews the advances in our knowledge of the antiviral immune response with particular reference to the selection of attenuated mumps virus strains used in different vaccine formulations. The ability of mumps viruses to evade the in...

BACKGROUND Mumps outbreaks in populations with high 2-dose measles-mumps-rubella (MMR) vaccine coverage raise the question whether a third dose of MMR vaccine (MMR3) is needed. However, data on the immunogenicity of MMR3 are limited. We assessed mumps virus neutralizing antibody levels pre- and post-MMR3 in a nonoutbreak setting. METHODS Mumps antibody titers were assessed at baseline, 1 mont...

Poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. Despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is essential. For accurate vaccine evaluation, three types of cell lines including Hela, Hep2C and Vero were evaluated and compared using two methods of...

Here we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were tested using a fluorescent bead-based multiplex immunoassay. Overall seroprevalence was 90.9% with...

This paper considers the hypothesis that mumps vaccine may be an environmental factor for childhood diabetes and the difficulties assessing the available information about this. A review was undertaken of the published literature about mumps or mumps vaccine and diabetes mellitus in childhood. There has been considerable speculation about the role of wild mumps virus and mumps vaccine in the on...

Mumps is a highly contagious viral infection that became rare in most industrialized countries following the introduction of measles-mumps-rubella (MMR) vaccine in 1967. The disease, however, has been re-emerging with several outbreaks over the past decade. Many clinicians have never seen a case of mumps. To assist frontline healthcare providers with detecting potential cases and initiating cri...

BACKGROUND The number of cases of mumps in the UK has increased during 2004-2005. Understanding why some people are more susceptible to mumps infection will help target vaccination and other control measures in the future. This paper describes a mumps outbreak in a boarding school in Scotland (October to November 2004). OBJECTIVES To describe the characteristics of cases in a mumps outbreak; ...