In recent years, increasing attention has been devoted to the problem of the stability of multivariable regression models, understood as the resistance of the model to small changes in the data on which it has been fitted. Resampling techniques, mainly based on the bootstrap, have been developed to address this issue. In particular, the approaches based on the idea of "inclusion frequency" cons...

Two multivariable problems of general interest are factor analysis and regression. This paper examines partial least squares (PLS) as a tool for both problems. For single output data sets, the familiar PLS algorithm is applicable to both problems. For multiple output problems the familiar PLS algorithm 1, 2, 3] (called fact-PLS in this paper) is appropriate for factor analysis. However fact-PLS...

This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regress...

Using the North American Rheumatoid Arthritis Consortium genome-wide association dataset, we applied ridged, multiple least-squares regression to identify genetic variants with apparent unique contributions to variation of anti-cyclic citrullinated peptide (anti-CCP), a newly identified clinical risk factor for development of rheumatoid arthritis. Within a 2.7-Mbp region on chromosome 6 around ...

BACKGROUND UNICEF and WHO recommend colostrum as newborns' perfect food that should be initiated within the first hour after birth. OBJECTIVE To assess colostrum avoidance practices and associated factors among mothers of children aged <24 months in Raya Kobo district, North-eastern Ethiopia. METHODS A quantitative community-based cross-sectional study supplemented by qualitative method was...

Background: The ”July effect” is a colloquialism asserting an increased rate of errors at the start of the academicyear in teaching hospitals. This retrospective population-based study evaluated for the presence of the July effect inperforming shoulder arthroplasty.Methods: Using the Nationwide Inpatient Sample for 2002 through 2011, a total of 178,590 patients undergoingshoulder arthroplasty a...

Background:  The primary aim of this study was to determine predictors of missed research appointments in a prospective  andomized placebo injection-controlled trial with evaluations 1 to 3 and 5 to 8 months after enrollment.   Methods:  This study represents a secondary use of data from 104 patients that were enrolled in a prospective randomized  ontrolled trial of dexamethasone versus lidocai...

Background: Proximal femur fractures are prevalent among the elderly and associated with substantial morbidity,mortality, and early readmission. Early readmission is gaining popularity as a measure of quality of hospital care and canlower reimbursement. A better understanding of the patient and treatment characteristics associated with readmissionmay help inform program improvement initiatives....

Background Stigmatizing attitudes among healthcare providers are an important barrier to accessing services among people living with HIV (PLHIV). This cross-sectional study aimed to assess the status and correlates of HIV-related stigma among healthcare providers in Kerman, Iran.   M...

BACKGROUND Availability of user-friendly statistical software has increased the application of multivariable logistic regression (MLR) in the medical journal many fold. The reporting quality in terms of checking assumptions, model building strategies, proper coding, and report format need proper care and attention to communicate correct and reliable model results. OBJECTIVE The objective of t...