Cigarette smoking is a well-known risk factor in the development and progression of malignant diseases. Nicotine, the major constituent in cigarette smoke, has also shown negative effects on stem cells. Mesenchymal stem cells (MSCs) have been widely demonstrated to migrate into tumors and play key roles in cancer progression. However, the mechanisms by which nicotine impacts MSCs and tumorigene...

Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high e...

recent findings in stem cell biology have opened a new window in regenerative medicine. the endometrium possesses mesenchymal stem cells (mscs) called endometrial stem cells (enscs) having specific regenerative properties linked to adult stem cells. they contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. many clinical trials were undertaken to asce...

Cord tissue fills the umbilical cord around the blood vessels and contains types of stem cells (mesenchymal stem cells or MSCs) that are not generally found in cord blood. MSCs are the stem cells that give rise to many of the "support tissues" in the body, including bone, cartilage, fat and muscle. Umbilical Cord Tissue cells (UCTs) possessing the capacity to differentiate into various cell typ...

In recent years, human mesenchymal stem cells (multipotential stromal cells) from bone marrow (hMSCs) have attracted enormous attention owing to their broad therapeutic potential. One of the problems in the overall therapeutic use of hMSCs has been the significant variability in the culture conditions used for their isolation and expansion. Since the seminal publications by Friedenstein and col...

OBJECTIVE To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. SAMPLE Tissues from 10 equine cadavers. PROCEDURES Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomed...

background: although cervical cancer mortality has reduced during last years, but it is still leading cause of mortality among women. many efforts have performed to develop new drugs and strategy to cure cervical cancer. mesenchymal stem cells (mscs) have many advantages that make them a suitable choice as a cell therapeutic agent in cancer treatment. there are different transfection methods fo...

Great confusion still exists amongst cell biologists, musculoskeletal and other specialists interested in regenerative medicine regarding the in vivo identity of human bone marrow (BM) mesenchymal stem cells (MSCs). Contrary to views held in some quarters, methods for the robust identification and purification of BM MSCs are now well established. Human BM MSCs represent a phenotypically homogen...

Traumatic brain injury is one of the major causes of brain function impairments and surgery is involved in the treatment program of many cases although it cannot rescue the brain functions completely and is confined to reduce the second injury .in this study we aimed to investigate the effects of mesenchymal stem cells encapsulated in RADA1- GGS IKVAV, surgically injected into the lesion site. ...