BACKGROUND Although the natural history of multiple sclerosis has been charted extensively, it is still not known whether the trajectory of disability accumulation has changed in the era of disease-modifying therapies (DMTs). OBJECTIVE The objective of this study was to examine trends in Multiple Sclerosis Severity Score (MSSS) with regard to calendar year of enrollment into the New York Stat...

BACKGROUND Progression in disability as measured by increase in the Expanded Disability Status Scale (EDSS) is commonly used as outcome variable in clinical trials concerning multiple sclerosis (MS). In this study, we addressed the question, whether there is a linear relationship between disability status and health related quality of life (HRQOL) in MS. METHODS 7305 MS patients were sent a q...

• As described in more detail in Ruutiainen et al. (2015), 553 Finnish persons with MS (PwMS) drawn from the membership register of the national patient society completed a postal survey, which aimed at determining the economic and health-related quality of life (HRQoL) burden of MS in Finland. • Survey questionnaire included self-administered EDSS and MSIS-29. EDSS score ranges from 0 to 9 and...

OBJECTIVES The aim of the study was to determine temporal orientation in patients diagnosed with RR-MS as compared with that of healthy individuals; to analyse self-evaluated acceptance levels in terms of physical and psychological condition and self-reliance; an attempt to identify factors of illness acceptance in patients with RR-MS including temporal perspective. METHODS Acceptance of Illn...

AIM The aims of this study were to determine the reliability, responsiveness and minimally important change score of the Multiple Sclerosis Impact Scale (MSIS)-29 physical using the Expanded Disability Status Scale (EDSS) as an anchor measure. METHODS 214 patients with multiple sclerosis (MS) (EDSS 0-8.5) had concurrent MSIS-29 and EDSS assessments at baseline and at up to 4 years of follow-u...

-In this paper, an asymptotically stabilizing composite feedback control is proposed for a class of two-time-scale neutral systems with multiple time delays. The state feedback controls for the asymptotic stability of the slow neutral subsystem and the fast subsystem are first presented. Moreover, a stability bound   of small positive parameter  is given such that the original system under t...

End-to-end QoS control over best-effort and differentiated service networks which exhibit variability in their exported service properties looms as an important challenge. In previous work, we have shown how packet-level adaptive FEC can be used in dynamic networks to facilitate invariant user-specified QoS in an end-to-end manner. This paper addresses two important problems—self-similar bursti...