conclusions we found ccd and rsm very effective in optimizing hib culture conditions, and hib biomass production was greatly influenced by ph and incubation temperature. therefore, optimization of the growth factors to maximize hib production can lead to 1) an increase in bacterial biomass and prp productions, 2) lower vaccine prices, 3) vaccination of more susceptible populations, and 4) lower...

introduction: glabrous skin and hairy skin are innervated by different types of noxious fibers. however, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. methods: in this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...

matrix metalloproteinases (mmps) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. mmps have been demonstrated to increase the permeability of the blood–brain barrier (bbb) by degrading the compone...

In this study, the method of multiple scales is used to perform a nonlinear vibration analysis of a mechanical system in two cases; with dry and lubricated clearance joints. In the dry contact case, the Lankarani-Nikravesh model is used to represent the contact force between the joined bodies. The surface elasticity is modeled as a nonlinear spring-damper element. Primary resonance is discussed...

central composite design (ccd; 5 levels and 3 factors) and response surface regression (rsreg) were used to evaluate the response of broiler chicks [average daily gain (adg), feed conversion ratio (fcr) and feed intake (fi)] to dietary requirements of  lysine (lys), methionine (met) and threonine (thr). a total of 60 battery brooder units of 6 birds each were assigned to 15 diets in 3 replicati...