Uterine leiomyomas are common benign smooth muscle tumors that impose a major burden on women's health. Recent sequencing studies have revealed recurrent and mutually exclusive mutations in leiomyomas, suggesting the involvement of molecularly distinct pathways. In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility g...

The relationship between benign uterine leiomyomas and their malignant counterparts, i.e. leiomyosarcomas and smooth muscle tumors of uncertain malignant potential (STUMP), is still poorly understood. The idea that a leiomyosarcoma could derive from a leiomyoma is still controversial. Recently MED12 mutations have been reported in uterine leiomyomas. In this study we asked whether such mutation...

Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing reco...

Thirty-six leiomyomas from the same number of patients that were heterogeneous on MR imaging were evaluated for analyzing their MR patterns and for differentiating each type of secondary changes by means of MR imaging-pathologic correlation. The tumors with a mean diameter of 9 cm could be classified into 4 patterns depending on the morphological appearance of signal intensity: speckled (n = 14...

Uterine lipleiomyoma is a rare variant of leiomyoma with reported prevalence of 0.03% to 0.2%. Lipoleiomyomas of the uterus are typically found in postmenpausal women and in most cases are asymptomatic and are associated with ordinary leiomyomas. This rare tumor is composed of an admixture of mature adipocytes and benign smooth muscle cells. The histogenesis for this tumor is still controversia...

BACKGROUND The possible association between allergy and neoplastic disorders has been the subject of many investigations but no general relationship has been determined. Little attention, however, has been paid to the possible role of allergy in the clinical manifestations of these diseases. In this study, the role of allergy in the susceptibility to uterine leiomyomas and in their growth was i...

Esophageal leiomyoma derived from the muscularis mucosae (MM) is a rare condition, and the optimal modality for diagnosis and treatment is controversial. Endoscopic ultrasonography can provide an accurate image of esophageal layer structure, providing information on lesion suitability for potential endoscopic therapy. We attempted to investigate the diagnostic value of a transendoscopic balloon...

Benign metastasizing leiomyoma (BML) is a very rare condition and is characterized by the presence of benign smooth muscle tumours in organs distant from the uterus, most commonly the lung. It generally affects women of reproductive age and prognostic is usually excellent. However, the course of the disease is unpredictable. We report here the case of a 76-year-old woman with a previous medical...

Leiomyomas are an uncommon manifestation of neurofibromatosis type 1 (NF-1) and occur most often in the gastrointestinal tract. Here, they have a proclivity for the proximal small bowel and tend to be multiple. Urinary tract involvement by NF-1 is usually in the form of neurofibromas, and leiomyomas are exceptionally rare. This report describes a case of solitary leiomyoma occurring in a 49 yea...

Background: There has previously been a concern about whether it is safe to use minimally invasive methods to treat pedunculated subserosal uterine leiomyomas. The purpose of our study is to evaluate the safety of magnetic resonance-guided focused ultrasound (MRgFUS) ablation of pedunculated subserosal uterine leiomyomas. Methods: All cases of MRgFUS ablations performed at our institution from ...