The populations of pathogens in individual hosts have many of the characteristics of multicellular organisms, or individuals. These populations go through a life cycle within a host and they reproduce by founding daughter populations in new hosts. Natural selection shapes the life history characteristics of pathogen populations--life expectancy, trade-offs in the allocation of resources between...

Multicellular organisms create complex patterned structures from identical, unreliable components. Learning how to engineer such robust behavior is important to both an improved understanding of computer science and to a better understanding of the natural developmental process. Earlier work by our colleagues and ourselves on amorphous computing demonstrates in simulation how one might build co...

The evolution of multicellularity was one of the key innovations in the history of life on Earth. Virtually all morphological and ecological diversity in macro-organisms builds upon the evolutionary potential associated with multicellularity. We examined the potential for ecological diversity to rapidly arise following transitions to multicellularity. Replicate microcosms containing the yeast S...

The organization of the living world is hierarchical—lower level units group together and cooperate to form higher level units of organization (genes, chromosomes, bacterialike cells, eukaryotic-like cells (cells in cells), multicellular organisms and societies). How this came about is far from clear. What is clear is that the major landmarks in the diversification of life have involved transit...

An epithelial duct is a well-defined multicellular structure composed of tightly packed cells separating and protecting body compartments that are used for enzyme secretion and its transport across the internal. The structural and functional integrity (homeostasis) of such ducts is vital in carrying many life functions (breathing, lactation, production of hormones). However, the processes invol...

The formation of multicellular communities known as biofilms is the part of bacterial life cycle in which bacteria display cooperative behaviour and differentiated phenotypes leading to specific functions. Bacillus subtilis is a Gram-positive bacterium that has served for a decade as a model to study the molecular pathways that control biofilm formation. Most of the data on B. subtilis biofilms...

Individuality is a complex trait, yet a series of stages each advantageous in itself can be shown to exist allowing evolution to get from unicellular individuals to multicellular individuals. We consider several of the key stages involved in this transition: the initial advantage of group formation, the origin of reproductive altruism within the group, and the further specialization of cell typ...

The transition from unicellular, to colonial, to larger multicellular organisms has benefits, costs, and requirements. Here we present a model inspired by the volvocine green algae that explains the dynamics involved in the unicellular-multicellular transition using life-history theory and allometry. We model the two fitness components (fecundity and viability) and compare the fitness of hypoth...

Multicellular organisms with different tissues and organs are three-dimensional complex life forms both temporal spatial specificity of gene expression. While can be obtained through assays analyses at time points, has only just been investigated the macroscopic organismal level. Recent developments in single-cell sequencing technologies have enabled high-throughput analysis spatially specific ...