Reconstruction of large oral mucosa defects is often challenging, since the shortage of healthy oral mucosa to replace the excised tissues is very common. In this context, tissue engineering techniques may provide a source of autologous tissues available for transplant in these patients. In this work, we developed a new model of artificial oral mucosa generated by tissue engineering using a fib...

BACKGROUND: The biopsy of an oral mucosal lesion is a minor operation. Pain might be an unpredictable consequence of the oral mucosal biopsy. The aim of this study was to examine the incidence and severity of post-operative pain following the biopsy of oral mucosal lesions in patients attending in an oral medicine department of Kerman Dental School. METHODS: Visual analogue scale (VAS) was used...

introduction: leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. p53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (pcna) is a proliferative marker. the aim of this study was to evaluate the immunohistochemical expressions of p53 and pcna in oral leukopla...

lipoma is a benign mesenchymal tumor of fat with uncertain pathogenesis. although the most common mesenchymal neoplasm in trunk and proximal portions of the extremities, it is rarely seen in the oral cavity. oral lipomas are clinically soft, smooth-surfaced nodular masses that mostly are less than 3 cm in size. typically the tumor is asymptomatic unless bitten or become noticeable because of th...

The aim of this study was to determine histological changes in rats’ oral mucosa at induced postmenopausal oestrogen decrease and after administration of raloxifene and 17β-oestradiol. Wistar female rats were ovariectomized and divided into experimental groups; basal – after ovariectomy without drugs BOV, taking raloxifene RA and oestradiol – OVH (10 rats per group). Additionally, 10 rats witho...

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by peripheral antigen which homed to the colonic mucosa. The clonal distribution of I...

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by peripheral antigen which homed to the colonic mucosa. The clonal distribution of ...

Six intracellular hydrolases known to be associated with lysosomes in rat liver were found in rat intestinal mucosa. The extent to which they were particulate-bound and the degree of enzyme release when the particulate fractions were suspended in hypotonic media followed the same pattern in both mucosa and liver. The specific activities of the mucosa enzymes were either comparable to or slightl...

The molecular pathogenesis of Barrett's esophagus is poorly understood. Evidence suggests that at a phenotypic level, the metaplastic process begins with the transformation of squamous epithelium in the distal esophagus to cardiac mucosa, which subsequently becomes intestinalized. The homeobox gene Cdx-2 has been shown to be an important transcriptional regulator of embryonic differentiation an...