Aim: to study the effect of N-acetylcysteine (NAC) on dynamics clinical and radiological changes in patients with COVID-19. Patients Methods: included 111 moderate severe forms COVID-19 pneumonia 2nd 3rd stage according computed tomography (CT). The median age was 49,25 years. Group 1 (n=55) received standard therapy: favipiravir, enoxaparin sodium regimen, dexamethasone. Antibacterial therapy ...

The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglyc...

Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic diet can drastically alter bacterial populations (i.e., dysbiosis) leading to activation of pro-inflammatory mechanisms and metabolic endotoxemia, therefore promoting insulin resistance and cardiometabo...

Methods 100 subjects suffering from bronchial asthma were enrolled for this study from 2012 January to February, after obtaining consent of the participants and ethical committee approval. The bronchial asthma severity was graded as severe pefr <200ltrs\Mt, moderate 200-300ltrs \Mt, mild 300-400ltrs\Mt. For this study moderate and mild categories were selected. Furthermore 20% (10% each of mode...

Work recently reviewed by Duran-Reynals,6 in whose laboratory this investigation was carried out, has provided facts which form the basis for a concept of the permeability of connective tissue. Tissue permeability has a normal constitutional state or tonus which can be increased by certain factors and decreased by others. Of the former, the most important are the spreading factors, some of whic...

N-acetylcysteine (NAC), the acetylated variant of the amino acid L-cysteine, is an excellent source of sulfhydryl (SH) groups, and is converted in the body into metabolites capable of stimulating glutathione (GSH) synthesis, promoting detoxification, and acting directly as free radical scavengers. Administration of NAC has historically been as a mucolytic agent in a variety of respiratory illne...

Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result...

The superiority of formol-ether concentration over the well known zinc sulphate flotation method was demonstrated by Ritchie, Pan, and Hunter (1952). In the latter method the heavier ova (Schistosoma, Fasciola) fail to rise to the surface; with formol-ether, a sedimentation technique, all parasites go to the bottom. The increased yield of positive findings with all types of faecal parasites, th...