BACKGROUND Disruption of the plantar plate of the lesser metatarsophalangeal (MTP) joints leads to significant instability. Despite the fact that plantar plate disorders are common, the best mode of treatment remains controversial with operative treatments having variable and somewhat unpredictable clinical outcomes. METHODS Lesser MTP joints from the second, third, and fourth toes from fresh...

The small sample size problem and the difficulty in determining the optimal reduced dimension limit the application of subspace learning methods in the gait recognition domain. To address the two issues, we propose a novel algorithm named multi-linear tensor-based learning without tuning parameters (MTP) for gait recognition. In MTP, we first employ a new method for automatic selection of the o...

Peripheral blood monocytes were isolated from normal human donors by separation on a continuous Percoll gradient and adherence to yield preparations of blood monocytes with a high degree of purity (greater than 99%). The monocytes were incubated in vitro with medium alone or with multilamellar liposomes that contained either a lipophilic derivative of muramyl dipeptide, muramyl tripeptide (MTP-...

Excessive production of triglyceride-rich VLDL, which can result from dietary overindulgence, underlies metabolic syndrome--a combination of disorders including high blood pressure, obesity, high triglyceride, and insulin resistance--and places individuals at increased risk of developing cardiovascular disease and type 2 diabetes. However, the link between VLDL overproduction and insulin resist...

This is the first clinical implementation of the Multistate Tuberculosis Pharmacometric (MTP) model describing fast-, slow-, and nonmultiplying bacterial states of Mycobacterium tuberculosis. Colony forming unit data from 19 patients treated with rifampicin were analyzed. A previously developed rifampicin population pharmacokinetic (PK) model was linked to the MTP model previously developed usi...

We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis, secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS-7 cells that expressed C-terminally truncated forms of apoB (from apoB15 to apoB94) with or without the large subunit of human MTP. With the exception of apoB15 and apoB18, secretion of all of the apoB forms was stimula...

The principal extracellular lesions of age-related maculopathy (ARM), the leading cause of vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between the retinal pigment epithelium (RPE) and its blood supply. With age, 80-100 nm solid particles containing esterified cholesterol (EC) accumulate in normal BrM, and apolipoprotein B (apoB) immunoreactivity is detecta...

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Introduction Cheilectomy surgery has been shown to provide pain relief for patients with hallux rigidus [1], however limited data exists regarding the effectiveness of this surgery in reestablishing normal first metatarsophalangeal (1st MTP) joint kinematics. A recent dynamic gait study has reported only modest improvement in 1st MTP motion following surgery, thus implicating the persistence of...