نتایج جستجو برای: mtor

تعداد نتایج: 16868  

2016
Edyta Ulińska Katarzyna Mycko Elżbieta Sałacińska-Łoś Agata Pastorczak Alicja Siwicka Wojciech Młynarski Michał Matysiak

AIM OF THE STUDY To characterise expression of mTOR (mammalian target of rapamycin) in childhood B-cell acute lymphoblastic leukaemia (ALL), and to evaluate a possible link between mTOR and clinical characteristics. MATERIAL AND METHODS The examined group consisted of 21 consecutive patients, aged 1-18 years, diagnosed with B-cell ALL in 2010, and 10 relapsed B-cell ALL patients diagnosed for...

Journal: :Blood 2011
Balachandra K Gorentla Chi-Keung Wan Xiao-Ping Zhong

The engagement of TCR induces T-cell activation, which initiates multiple characteristic changes such as increase in cell size, cell division, and the production of cytokines and other effector molecules. The mammalian target of rapamycin (mTOR) regulates protein synthesis, transcription, cell survival, and autophagy. Critical roles of mTOR in T-cell activation and effector/memory differentiati...

Journal: :American journal of physiology. Cell physiology 2014
Ian Henry Lambert Jane Vendelbo Jensen Per Amstrup Pedersen

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that modulates translation in response to growth factors and alterations in nutrient availability following hypoxia and DNA damage. Here we demonstrate that mTOR activity in Ehrlich Lettré ascites (ELA) cells is transiently increased within minutes following osmotic cell swelling and that inhibition of phosphatidylinositol-3-phos...

2014
Sharmila Mallya Briana A. Fitch J. Scott Lee Lomon So Matthew R. Janes David A. Fruman

Inhibitors of the mechanistic target of rapamycin (mTOR) hold promise for treatment of hematological malignancies. Analogs of the allosteric mTOR inhibitor rapamycin are approved for mantle cell lymphoma but have limited efficacy in other blood cancers. ATP-competitive "active-site" mTOR inhibitors produce more complete mTOR inhibition and are more effective than rapamycin in preclinical models...

2016
Dohyun Park Heeyoon Jeong Mi Nam Lee Ara Koh Ohman Kwon Yong Ryoul Yang Jungeun Noh Pann-Ghill Suh Hwangseo Park Sung Ho Ryu

Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as reduction of inflammation and induction of cancer cell death. Although various resveratrol targets have been suggested, the molecule that mediates resveratrol-induced autophagy rema...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Antonella Caccamo Vito De Pinto Angela Messina Caterina Branca Salvatore Oddo

Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. However, whether hyperactive mTOR plays a role in the cognitive deficits associated with AD remains elusive. Here, we genetically reduced mTOR signaling in the brains of Tg2576 mice, a widely used animal model of AD. We f...

Journal: :Science 2011
Peggy P Hsu Seong A Kang Jonathan Rameseder Yi Zhang Kathleen A Ottina Daniel Lim Timothy R Peterson Yongmun Choi Nathanael S Gray Michael B Yaffe Jarrod A Marto David M Sabatini

The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined the mTOR-regulated phosphoproteome by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries...

Journal: :Molecular cell 2011
Daming Gao Hiroyuki Inuzuka Meng-Kwang Marcus Tan Hidefumi Fukushima Jason W Locasale Pengda Liu Lixin Wan Bo Zhai Y Rebecca Chin Shavali Shaik Costas A Lyssiotis Steven P Gygi Alex Toker Lewis C Cantley John M Asara J Wade Harper Wenyi Wei

The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of the mTOR network. DEPTOR stability is governed by the 26S-proteasome through a largely unknown mechanism. Here we describe an mTOR-dependent phosphorylation-driven pathway for DEPTOR destruction via SCF(βTrC...

Journal: :Endocrine-related cancer 2010
Luisella Righi Marco Volante Ida Rapa Veronica Tavaglione Frediano Inzani Giuseppe Pelosi Mauro Papotti

Among alternative therapeutic strategies in clinically aggressive neuroendocrine tumors (NETs) of the lung, promising results have been obtained in experimental clinical trials with mammalian target of rapamycin (mTOR) inhibitors, though in the absence of a proven mTOR signaling activation status. This study analyzed the expression of phosphorylated mTOR (p-mTOR) and its major targets, the ribo...

2012
Jae Sung You John W. Frey Troy A. Hornberger

Signaling by mTOR is a well-recognized component of the pathway through which mechanical signals regulate protein synthesis and muscle mass. However, the mechanisms involved in the mechanical regulation of mTOR signaling have not been defined. Nevertheless, recent studies suggest that a mechanically-induced increase in phosphatidic acid (PA) may be involved. There is also evidence which suggest...

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