Retrospective, single-center review between January 2010 and June 2020. We included 134 patients (93 male) with symptomatic ipsilateral carotid stenosis ischemic brain lesions assessed by diffusion-weighted magnetic resonance imaging (DW-MRI) RAPID processing underwent endarterectomy (CEA). Patients who CEA within 48 hours of symptoms suffered a significantly higher rate postoperative stroke (e...

OBJECTIVE To predict long-term disability outcomes in TEMSO core (NCT00134563) and extension (NCT00803049) studies in patients with relapsing forms of MS treated with teriflunomide. METHODS A post hoc analysis was conducted in a subgroup of patients who received teriflunomide in the core study, had MRI and clinical relapse assessments at months 12 (n = 552) and 18, and entered the extension. ...

Diffusion-weighted (DW) MRI is a powerful modality for studying microstructure in normal and pathological tissues. The accuracy derived from DW MRI depends on the acquisition of quality images, and on a precise assessment of the b-values involved. Conventional DW MRI tends to be of limited use in regions suffering from large magnetic field or chemical shift heterogeneities, which severely disto...

BACKGROUND In the UK, prostate cancer (PC) is the most common cancer in men. A diagnosis can be confirmed only following a prostate biopsy. Many men find themselves with an elevated prostate-specific antigen (PSA) level and a negative biopsy. The best way to manage these men remains uncertain. OBJECTIVES To assess the diagnostic accuracy of magnetic resonance spectroscopy (MRS) and enhanced m...

BACKGROUND The correlation between the histologic grades and the apparent diffusion coefficient (ADC) in head and neck squamous cell carcinomas (HNSCCs) remains unclear. This study aimed to evaluate the potential of diffusion-weighted MRI (DW-MRI) at both standard and high b values to differentiate the histologic grades of HNSCC. METHODS In all, 54 consecutive patients with HNSCCs (34 well-di...

There is a need for biomarkers that are useful for noninvasive imaging of tumor pathophysiology and drug efficacy. Through its use of endogenous water, diffusion-weighted MRI (DW-MRI) can be used to probe local tissue architecture and structure. However, most DW-MRI studies of cancer tissues have relied on simplistic mathematical models, such as apparent diffusion coefficient (ADC) or intravoxe...

This study is aimed to correlate apparent diffusion coefficient (ADC) values and clinical T-stage, serum PSA, pathology Gleason scores. We also further analyzed whether ADC values could be used to appropriately define the risk groups. 135 biopsy-proven, radiotherapy-(RT)-treated, prostate cancer patients who underwent pre-RT DW-MRI and standard T2W pelvic MRI were included. ADC and normalized A...

BACKGROUND The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by 18F-FDG-PET/CT and diffusion-weighted MRI (DW-MRI). METHODS Human BRAF-V600-mutant melanoma (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged by 18F-FDG-PET/CT and DW-MRI before (day 0) and after (day 7) a ...

PURPOSE We aimed to evaluate the effectiveness of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the diagnosis of acute appendicitis and differentiation of perforated and nonperforated appendicitis cases, with histopathologic correlation. MATERIALS AND METHODS Sixty consecutive patients (34 males, 26 females; mean age, 35.6±15.5 years...