An interaction that gets things started he nuclear envelope clearly helps regulate eukaryotic DNA replication, but many of the molecular pieces of this process are still unknown. On page 177, Martins et al. describe a novel, direct interaction between the nuclear envelope and the genome, mediated by the inner nuclear membrane protein LAP2b and the nuclear matrix– associated protein HA95, that i...

Intracellular cycling of the cation-dependent mannose 6-phosphate receptor (CD-MPR) between different compartments is directed by signals localized in its cytoplasmic tail. A di-aromatic motif (Phe18-Trp19 with Trp19 as the key residue) in its cytoplasmic tail is required for the sorting of the receptor from late endosomes back to the Golgi apparatus. However, the cation-independent mannose 6-p...

Herpes simplex virus 1 mutants lacking the gene encoding glycoprotein D (gD) and the gD normally present in the envelope of the virus (gD(-/-) stocks) or mutants lacking the gD gene but containing trans-induced gD in their envelopes (gD(-/+)) cause apoptosis in human SK-N-SH cells. The gD(-/-) virions are taken up by endocytosis and are degraded, whereas gD(-/+) viruses replicate but produce gD...

OBJECTIVE The objective of this study was to demonstrate the sensitivity and specificity of multislice computed tomography (CT) for diagnosis of orbital fractures following different protocols, using an independent workstation. MATERIALS AND METHODS CT images of 36 patients with maxillofacial fractures (symptomatic to orbit region) who were submitted to multislice CT scanning were analyzed, r...

The article is devoted to the formation and development of organizational structure healthcare in MPR 1920s–1960s. In course health care, growing role this institution increasing involvement most important social processes state can be traced. solution issues field was direction policy government MPR.

AIM Good medication adherence may decrease the probability of worse outcomes and reduce unnecessary medical care costs. This study aims to evaluate medication adherence for people on statin therapy. METHODS National health insurance databases were analyzed from January 1, 2001, to December 31, 2007. Study samples were patients of 45 years and older adults who took statin for the first time du...

This paper presents a new adaptive bandwidth allocation scheme to prevent handoff failure in wireless cellular networks, known as the measurement-based preassignment (MPr) technique. This technique is particularly useful in micro/pico cellular networks which offers quality-of-service (QoS) guarantee against call dropping. The proposed MPr scheme distinguishes itself from the well-known guarded ...

The Optimized Link State Routing (OLSR) protocol is a well-known route discovery protocol for ad-hoc networks. OLSR optimizes the flooding of link state information through the network using multipoint relays (MPRs). Only nodes selected as MPRs are responsible for forwarding control traffic. Many research papers aim to optimize the selection of MPRs with a specific purpose in mind: e.g., to min...

BACKGROUND AND PURPOSE We prospectively evaluated the influence of different imaging techniques (time-of-flight MR angiography [TOF-MRA], contrast-enhanced MR angiography [CE-MRA], multisection CT angiography [CTA]) and postprocessing methods (maximum intensity projection [MIP], multiplanar reformation [MPR]) on carotid artery stenosis grading. MATERIALS AND METHODS Fifty patients (34 men, 16...

A cross-layer design approach is proposed that can be used to optimize the cooperative use of multi-packet reception (MPR) and network coding. A simple and intuitive model is constructed for the behavior of an opportunistic network coding scheme called COPE proposed by Katti et. al., MPR, the 802.11 MAC, and their combination. The model is then applied to key small canonical topology components...