نتایج جستجو برای: mpk

تعداد نتایج: 187  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
M Machius J L Chuang R M Wynn D R Tomchick D T Chuang

Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We report a three-dimensional structure of a member of the mPK family, rat branched-...

Journal: :Current Biology 2002
Mitsue Ohmachi Christian E Rocheleau Diane Church Eric Lambie Tim Schedl Meera V Sundaram

Kinase Suppressor of Ras (KSR) is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK, and ERK. However, the precise role of KSR is not well understood, and some observations have suggested that KSR might act in a parallel pathway. In C. elegans, ksr-1 is only required for a specific Ras-mediated process (sex myoblast migration) and is a nones...

2016
Maria João Gravato-Nobre Filipa Vaz Sergio Filipe Ronald Chalmers Jonathan Hodgkin

Little is known about the relative contributions and importance of antibacterial effectors in the nematode C. elegans, despite extensive work on the innate immune responses in this organism. We report an investigation of the expression, function and regulation of the six ilys (invertebrate-type lysozyme) genes of C. elegans. These genes exhibited a surprising variety of tissue-specific expressi...

2012
Qiyan Li Michael S. Valerio Keith L. Kirkwood

In periodontal disease, host recognition of bacterial constituents, including lipopolysaccharide (LPS), induces p38 MAPK activation and subsequent inflammatory cytokine expression, favoring osteoclastogenesis and increased net bone resorption in the local periodontal environment. In this paper, we discuss evidence that the p38/MAPK-activated protein kinase-2 (MK2) signaling axis is needed for p...

2013
Maria Ermolaeva Björn Schumacher

DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow time for DNA repair, or induce cellular senescence and apoptosis to eliminate damaged cells.(2) In contrast to cell-autonomous DNA damage responses, it remains less clear how organisms respond to genome instability in certain cell ty...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
S Yeh H K Lin H Y Kang T H Thin M F Lin C Chang

Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu. Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, as well as MAP kinase phosphatase-1 (MPK-1), in the transfection assay, we found that HER2/Neu cou...

Journal: :The British journal of nutrition 2011
Alvin Ibarra Julien Cases Marc Roller Amparo Chiralt-Boix Aurélie Coussaert Christophe Ripoll

Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of r...

Journal: :Journal of rehabilitation research and development 2016
M Jason Highsmith Jason T Kahle Rebecca M Miro M Elaine Cress Derek J Lura William S Quillen Stephanie L Carey Rajiv V Dubey Larry J Mengelkoch

Microprocessor prosthetic knees (MPKs) have advanced technologically, offering new features to decrease impairment and activity limitations for persons with transfemoral amputation (TFA). The Genium knee is functionally untested, and functional differences between it and intact knees are unknown. This study sought to determine whether Genium use improves functional performance compared with the...

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