BACKGROUND The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neur...

Infections Shadi Parsaei, DO; Neeraja Ganeshraj, MPH; Alice P. Gu, MPH; Qian Liu, MPH; Carey-Ann D. Burnham, PhD; David K. Warren, MD, MPH, FIDSA, FSHEA; Michael A. Lane, MD, MSc; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Pediatrics, Pathology and Immunology, Washington University School of Medicine, St Louis, MO; Washingto...

BACKGROUND Methylphenidate (MPH) has been found to be an effective medication for attention-deficit/hyperactivity disorder (ADHD). However, there are neither consistent nor sufficient findings on whether psychiatric comorbidities and associated cognitive functions of ADHD are related to treatment response to MPH in ADHD children. OBJECTIVES This study investigated whether psychiatric comorbid...

1464. Influenza Vaccine Effectiveness among Elderly and Non-Elderly Adults Aged ≥45 Years in the United States, 2011–2012 to 2015–2016 Fiona P. Havers, MD, MHS; Kate Russell, MD, MPH; Jessie Chung, MPH; Arnold S. Monto, MD, FIDSA; Emily T. Martin, MPH, PhD; Edward A. Belongia, MD; Huong Q. McLean, PhD, MPH; Manjusha Gaglani, MBBS; Kempapura Murthy, MBBS, MPH; Richard K. Zimmerman, MD MPH, FIDSA...

ADHD is one of the most commonly diagnosed disorders during adolescence. Recently, significant increases in the diagnosis of ADHD have caused the prescription of the ADHD medication methylphenidate (MPH) to increase. MPH is a psychostimulant that blocks the dopamine transporter, which is responsible for dopamine reuptake at the synapse. The blockade of the dopamine transporter results in an inc...

BACKGROUND The present study examined pain perception in children and adolescents with ADHD and the interaction between pain perception and the administration of methylphenidate (MPH) in order to generate hypotheses for further research that will help to clarify the association between ADHD diagnosis, MPH treatment and pain perception. METHODS We included 260 children and adolescents of the "...

OBJECTIVE To compare methylphenidate (MPH) and dexamphetamine (DEX) in a sample of children with attention deficit hyperactivity disorder (ADHD). METHOD A total of 125 children with ADHD received both MPH (0.3 mg/kg twice daily) and DEX (0.15 mg/kg twice daily) for 2 weeks a double-blind, crossover study. Outcome measures were Conners' Parent Rating Scale-Revised, Conners' Teacher Rating Scal...

BACKGROUND Methylphenidate (MPH) is a psychomotor stimulant medication widely used for the treatment of attention-deficit/hyperactivity disorder (ADHD). Given the extent of prescribed use of MPH, and because MPH interacts with the same brain pathways activated by drugs of abuse, most research has focused on assessing MPH's potential to alter an individual's risk for adult drug addiction. Data e...

1464. Influenza Vaccine Effectiveness among Elderly and Non-Elderly Adults Aged ≥45 Years in the United States, 2011–2012 to 2015–2016 Fiona P. Havers, MD, MHS; Kate Russell, MD, MPH; Jessie Chung, MPH; Arnold S. Monto, MD, FIDSA; Emily T. Martin, MPH, PhD; Edward A. Belongia, MD; Huong Q. McLean, PhD, MPH; Manjusha Gaglani, MBBS; Kempapura Murthy, MBBS, MPH; Richard K. Zimmerman, MD MPH, FIDSA...

BACKGROUND Methylphenidate (MPH) is a commonly-used medication for the treatment of children with Attention-Deficit/Hyperactivity Disorders (ADHD). However, its prescription to adults with ADHD and narcolepsy raises the question of how the brain is impacted by MPH exposure during pregnancy. The goal of this study was to elucidate the long-term neurobiological consequences of prenatal exposure t...