Aortic dissection occurs when a tear develops in the wall of the aorta, which is rare in the young population. This fatal disorder is hard to diagnose, especially in young patients. We present the case of aortic dissection in a 15-year-old boy referred to the Emergency Department of Yazd University of Medical Sciences in November 2015. The patient presented to our department with sudden acute c...

Little is known of the environmental factors that initiate and promote disease. The aryl hydrocarbon receptor (AHR) is a key regulator of xenobiotic metabolism and plays a major role in gene/environment interactions. The AHR has also been demonstrated to carry out critical functions in development and disease. A qualitative investigation into the contribution by the AHR when stimulated to diffe...

Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of serelaxin in an in vivo mouse model of diabetes. Therefore, we tested the hypothesis in streptozotocin (STZ)-treated mice that serelaxin is able to reverse diabetes-induced vascular dysfunction and cardiac remodelling. Mice...

BACKGROUND Hyperglycemia and increased levels of methylglyoxal (MGO) can trigger the development of vascular complications in diabetes. Resveratrol and quercetin are red wine polyphenols with known beneficial cardiovascular properties, including an antioxidant capacity. This study evaluated whether resveratrol and/or quercetin could prevent in vitro-induced diabetic changes in neurogenic and va...

aorta is formed in a dynamic environment which gives rise to imbalances between many forces that tend to extend the diameter and length. furthermore, internal forces tend to resist this extension. impedance tomography can show this imbalance to stimulate the stenosis of aortic valve, growth of the elastic, collagen and to effectively reduce the stresses in the underlying tissue. in blood flow, ...

mycotic pseudoaneurysm of the ascending aorta is rare in patients undergoing coronary artery bypass graft (cabg) and usually caused by staphylococcus aureus. we describe a patient with a mycotic pseudoaneurysm of the ascending aorta at the proximal vein graft anastomosis site after cabg. culture from the sinus tract of the sternum and from the aneurysm sac was klebsiella pneumoniae. surgical te...

MR images shows an atherosclerotic plaque (arrow) of a mouse ascending aorta, which is confirmed by histology (B, HE staining, 1.25×). P=plaque. (C) Magnification of the same microscopic image of B, demonstrating the formation of a typical atherosclerotic plaque (P) with a ruptured fibrous cap (arrow), intraplaque fibrin deposition and hemorrhage, as well as foam cells accumulation. M=media. Fi...

Although macrophages and other immune system cells, especially T cells, have been shown to play disease-promoting roles in atherosclerosis, less is known about the role of antigen presenting cells. Functional, immune stimulating dendritic cells (DCs) have recently been detected in aortic intima, the site of origin of atherosclerosis. We had compared DCs with macrophages in mice with experimenta...

we report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. preoperative investigations such as transesophageal echocardiography (tee) confirmed the diagnosis of dissection. intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aort...