Are children superior to adults in consolidating procedural memory? This notion has been tied to "critical," early life periods of increased brain plasticity. Here, using a motor sequence learning task, we show, in experiment 1, that a) the rate of learning during a training session, b) the gains accrued, without additional practice, within a 24 hours post-training interval (delayed consolidati...

During motor learning, movements and underlying neural activity initially exhibit large trial-to-trial variability that decreases over learning. However, it is unclear how task-relevant neural populations coordinate to explore and consolidate activity patterns. Exploration and consolidation could happen for each neuron independently, across the population jointly, or both. We disambiguated amon...

Covert motor learning can sometimes transfer to overt behavior. We investigated the neural mechanism underlying transfer by constructing a two-context paradigm. Subjects performed cursor movements either overtly using arm movements, or covertly via a brain-machine interface that moves the cursor based on motor cortical activity (in lieu of arm movement). These tasks helped evaluate whether and ...

Aging has negative effects on motor and cognitive functions, therefore finding appropriate strategies to prevent the decline of these functions is necessary. It seems that cardiovascular fitness obtained by aerobic activity is a physiological mediator that explains the relationship between physical activity and improved cognitive performance. The aim of this research was to assess the effect...

Here we describe two studies linking perceptual change with motor learning. In the first, we document persistent changes in somatosensory perception that occur following force field learning. Subjects learned to control a robotic device that applied forces to the hand during arm movements. This led to a change in the sensed position of the limb that lasted at least 24 h. Control experiments rev...

Here we argue that general principles with regard to the contributions of the cerebellum, basal ganglia, and primary motor cortex to motor learning can begin to be inferred from explicit comparison across model systems and consideration of phylogeny. Both the cerebellum and the basal ganglia have highly conserved circuit architecture in vertebrates. The cerebellum has consistently been shown to...

Early decoding of motor states directly from the brain activity is essential to develop brain-machine interfaces (BMI) for natural motor control of neuroprosthetic devices. Hence, this study aimed to investigate the detection of movement information before the actual movement occurs. This information piece could be useful to provide early control signals to drive BMI-based rehabilitation and mo...

The equal division of chromosomes among daughter cells at mitosis involves a complex series of kinetochore-dependent chromosome movements. The kinetochore-associated CENP-E motor protein is critical for the sustained movement of chromosomes towards the metaphase plate during chromosome congression.

carnation etched ring virus (cerv) is a member of the caulimovirus genus of the caulimoviridae. the virus is the second most important virus of carnation around the world and the only dna virus among infecting viruses of carnation. the virus infected plants were collected from greenhouse in chenaran and two fragments of ~1500 bp and ~1000 bp respectively for coat protein and movement protein we...