نتایج جستجو برای: motor end plate
تعداد نتایج: 622852 فیلتر نتایج به سال:
The mechanism of depressant effects of Ca2+ on the acetylcholine (ACh)-activated ion channel conductance was studied in frog muscle fibers. Increasing the extracellular Ca2+ ( (Ca2+)o) suppressed the increase in the end-plate conductance induced by iontophoretic application of ACh and shifted the reversal potential for a neurally-induced end-plate current to a more negative value. The single ch...
Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. Thus, mice that do not process miRNA in SMNs exhibit hallmarks of spinal muscular atrophy (SMA), including sclerosis of the spinal cor...
The effects of neuromuscular blocking concentrations of hexamethomum and decamethonium on end-plate current parameters have been studied in frog sartorius nervemuscle preparations. In the presence of either drug, hyperpolarization of the cell membrane reduces the peak amplitude of the end-plate current despite the increase in driving force. The effect is larger for hexamethonium than for decame...
Gassel (1963) devised a method for direct measurement of femoral nerve conduction and found this useful in differentiating neuritis of the femoral nerve from other causes of proximal neurogenic and muscular diseases. He discussed the relevant anatomy of the terminal motor fibres in the skeletal muscles, with particular reference to the quadriceps femoris muscle. He also described the theoretica...
Several segments of spinal cord were removed from the cervical regions of stage-13 or -14 (day-2) chick embryos. After further incubation to day 17 or 18, the patterns of end-plate distribution and ATPase typing of muscle fibres in the anterior and posterior latissimus dorsi and the ulnimetacarpalis dorsalis, and the ATPase typing of the forearm muscles were examined. No differences from contro...
Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger transcription factor Gli1 is expresse...
A major goal in the study of vertebrate mitosis is to identify proteins that create the kinetochore-microtubule attachment site. Attachment sites within the kinetochore outer plate generate microtubule dependent forces for chromosome movement and regulate spindle checkpoint protein assembly at the kinetochore. The Ndc80 complex, comprised of Ndc80 (Hec1), Nuf2, Spc24, and Spc25, is essential fo...
In this article a new structure of PEM fuel cell end plate is presented. The new structure is known as a honeycomb sandwich panel. Several properties of the presented structure, such as mechanical and thermal behavior, as well as its advantages and disadvantages are introduced. The aim of this paper is to reduce the weight of the while maintaining a better compression force on the PEM fuel cell...
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