The cyclic cystine knot motif, as defined by the cyclotide peptide family, is an attractive scaffold for protein engineering. To date, however, the utilisation of this scaffold has been limited by the inability to synthesise members of the most diverse and biologically active subfamily, the bracelet cyclotides. This study describes the synthesis and first direct oxidative folding of a bracelet ...

The plant-dedicated mirror of the Regulatory Sequence Analysis Tools (RSAT, http://plants.rsat.eu ) offers specialized options for researchers dealing with plant transcriptional regulation. The website contains whole-sequenced genomes from species regularly updated from Ensembl Plants and other sources (currently 40), and supports an array of tasks frequently required for the analysis of regula...

Ruthenium-complexes of novel carbohydrate based pseudo-dipeptide ligands effectively and selectively catalyze the reduction of a broad range of aryl-alkyl ketones under ATH conditions. Excellent enantioselectivities (>99% ee) are obtained using aminosugars as the sole source of chirality.

Pumilio protein regulates translation of specific mRNAs in morphogenesis and germ-line development of the flies by binding nucleotide motifs GUUGU (A) and AUUGUA (B) in 3'untranslated regions. A human homologue, PUMILIO2 has been recently identified in the germ-line stem cells and the question was raised whether it regulates translation. We designed software to screen the GeneBank for A and B m...

MERIT (Multimedia Extensions of Retrieval Interaction Tools)1 provides a user-centered interface to a database covering European research programs, projects, and consortia in the field of information technology. The system supports the user by offering a selection of sample retrieval strategies, called “cases”, which are modifiable to meet situative requirements. The dialogue is focused by obje...

Dorsal Hippocampal neurons provide an allocentric map of space, characterized by three key properties. First, their firing is spatially selective, termed a rate code. Second, as animals traverse through place fields, neurons sustain elevated firing rates for long periods, however this has received little attention. Third the theta-phase of spikes within this sustained activity varies with anima...

one of the most important sits of sasanian period in iran from which the royal hunting plaques were recovered has been chal tarkhan of eshgh abad. there was a sasanian palace containing a considerable number of stucco representing variety of subject pointing to a deep understanding of sasanian stucco art. in spite of the researchers made by e.g. thompson and kroger on this plaques yet, there ha...

PreDREM is a database of DNA regulatory motifs and motifs modules predicted from DNase I hypersensitive sites in 349 human cell and tissue samples. It contains 845-1325 predicted motifs in each sample, which result in a total of 2684 non-redundant motifs. In comparison with seven large collections of known motifs, more than 84% of the 2684 predicted motifs are similar to the known motifs, and 5...

seals and clay sealings are the most important cultural material of sasanian period. there have been a few seals and bullas of various periods retained in the moghadam museum of tehran. these materials have not been introduced so far. authors of the present paper aim at to study and introduce the sasanian seals and bullas of this museum especially those bearing animal symbolic motifs. we do thi...

the interactions between southeastern sites of iranian plateau and western sites in susa and mesopotamia in the third millennium b.c is one of the most controversial aspects of the near eastern archaeology. it seems that with some structural changes in these sites from the middle of 4th millennium b.c that led to long distance trade between mesopotamia and indus valley, these sites were related...