Emerging evidence suggests that ubiquitination serves as a protein trafficking signal in addition to its well characterized role in promoting protein degradation. The yeast G protein alpha subunit Gpa1 represents a rare example of a protein that undergoes both mono- and poly-ubiquitination. Whereas mono-ubiquitinated Gpa1 is targeted to the vacuole, poly-ubiquitinated Gpa1 is directed instead t...

In the region of minimum porosity of particulate binary mixtures, heat exchange and permeability were found to be higher than the ones obtained with a mono-size packing built with the same small size particles used in the binary packing. This effect was noticed in the range of the particles size ratio 0.1–1.0. The obtained improvement on thermal performance is related to the increase of effecti...

OBJECTIVE To analyze the impact of the substitution of a rich diet in saturated fats with a rich diet in monounsaturated fats on anthropometric, metabolic and lipid profile in postmenopausal women. MATERIAL AND METHODS A prospective, longitudinal and comparative study where 18 postmenopausal women participated in two periods of dietary intervention of 28 days each one: 1) (SAT diet) consumed ...

Objective(s): Irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase I. Recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). Materials and Methods: In this study, irinotecan loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method to...

Abstract: SiC nano particles with mono dispersed distribution were synthesized by using of silicon alkoxides and phenolic resin as starting materials. After synthesis of sample, characterizations of the obtained powder were investigated via Fourier Transform Infrared Spectroscopy (FTIR) with 400-4000 cm-1, X-ray Diffractometry (XRD), Laser Particle Size Analyzing (LPSA), Si29 NMR analysis, Scan...

electrochemical behavior of the new mono and dinuclear co (iii)  complexes of  the types trans-[pyco((do)(doh)pn )(l)]pf6   and [{py co((do)(doh)pn)}2 (μ-dicyd)] (pf6)2   have been studied in acetonitrile solution.  all the  mono nuclear complexes  show two quasi- reversible reduction couples associate  to co(iii/ii)and  co(ii/i). each of these redox couples split to two  one electron  waves in...

Problem statement: To evaluate the frictional forces generated by five different orthodontic brackets when used in combination with stainless steel and NiTi archwires in dry conditions at physiological temperature. Approach: Five different types of maxillary canine brackets (Damon 3 MX, Step, Quick, Sprint, Mini Mono) with a slot size 0.022 inch were coupled with 0.016” and 0.019”×0.025” stainl...

Differently hydrogenated radio frequency-sputtered a-Si layers have been studied by infrared (IR) spectroscopy as a function of the annealing time at 350°C with the aim to get a deeper understanding of the origin of blisters previously observed by us in a-Si/a-Ge multilayers prepared under the same conditions as the ones applied to the present a-Si layers. The H content varied between 10.8 and ...

In Multipregnancies, The careful control of Number of follicles in stimulation cycles and Number of embryos transferred in ART cycles is so important. Just twin pregnancies are reason for racial death (12- 15%). The risk for CP in twin pregnancies is 8 times more and for Triple is 47 times more than simple ones.Approximately all prenatal problems increase in multiple pregnancies and therefore t...

TGF-beta activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-...