نتایج جستجو برای: momentum and bid

تعداد نتایج: 16834813  

Journal: :The Journal of Experimental Medicine 2000
Vivien R. Sutton Joanne E. Davis Michael Cancilla Ricky W. Johnstone Astrid A. Ruefli Karin Sedelies Kylie A. Browne Joseph A. Trapani

The essential upstream steps in granzyme B-mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the mitochondrial apoptotic pathway through direct cleavage of Bid; however, cleavage of procaspases was stalled when mitochondrial disruption was blocked by Bcl-2. The sensitivity of granzyme B-resistant Bcl-2-overexpressing FDC-P1 cells was restored by coexpression of wild-...

2016
Changshun Yu Shengmin Yan Bilon Khambu Xiaoyun Chen Zheng Dong Jianhua Luo George K. Michalopoulos Shangwei Wu Xiao-Ming Yin

Bid is a Bcl-2 family protein. In addition to its pro-apoptosis function, Bid can also promote cell proliferation, maintain S phase checkpoint, and facilitate inflammasome activation. Bid plays important roles in tissue injury and regeneration, hematopoietic homeostasis, and tumorigenesis. Bid participates in hepatic carcinogenesis but the mechanism is not fully understood. Deletion of Bid resu...

2011
Christer Andersson Ola Andersson Tommy Andersson

This paper considers the sealed bid and ascending auction, which both identifies the minimum Walrasian equilibrium prices and where truthful preference revelation constitutes an equilibrium. Even though these auction formats share many theoretical properties, there are behavioral aspects that are not easily captured. To explore this issue in more detail, this paper experimentally investigates w...

2015
Dan Han Shaoyu Hao Cheng Tao Qian Zhao Yumei Wei Zhengzheng Song Baosheng Li

BACKGROUND This study was designed to compare toxicities, disease control, and survival outcomes for limited disease small-cell lung cancer (LD-SCLC) treated with once daily (QD) versus twice daily (BID) radiotherapy. METHODS All of the patients received four to six cycles of platinum plus etoposide. In the QD group, irradiation was given via conventional radiotherapy with a dose of 60 Gy at ...

2004
Qiao Liu Rong Qi

This paper hypothesizes that more active informed trading and intense information production help investors detect the low persistence of accruals, and consequently reduce the magnitude of accruals mis-pricing. Applying both the Mishkin (1983) and the hedge-portfolio tests to subsamples sorted on the basis of a two-way classification – accruals and one of the information production measures, we...

Journal: :Cancer research 2009
Deborah L Hodge Jun Yang Matthew D Buschman Paul M Schaughency Hong Dang William Bere Yili Yang Ram Savan Jeff J Subleski Xiao-Ming Yin Thomas P Loughran Howard A Young

Large granular lymphocyte (LGL) leukemia is a clonal proliferative disease of T and natural killer (NK) cells. Interleukin (IL)-15 is important for the development and progression of LGL leukemia and is a survival factor for normal NK and T memory cells. IL-15 alters expression of Bcl-2 family members, Bcl-2, Bcl-XL, Bim, Noxa, and Mcl-1; however, effects on Bid have not been shown. Using an ad...

Journal: :Games and Economic Behavior 2017

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