نتایج جستجو برای: molecular mechanisms of pharmacological action
تعداد نتایج: 21261883 فیلتر نتایج به سال:
probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. the most predominant species that have been used as probiotic include lactobacilli and bifidobacteria. proper administration of probiotics could be efficient in the treatment of various disorders. however; their mechanism of action is poorly understood. the effects of ...
it was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (ap). it seems that some other types of mechanisms must be involved in ap propagation. in this article, we...
Pain is universally understood as a signal of disease and is the most common symptom about a disease. Modern clinical medicine and traditional medicine share common goals of alleviating pain and eliminating the causes of pain. Unfortunately, pharmaceutical drugs especially opioid analgesics often cause serious short- and long-term side-effects. As a result, more and more patients are turning t...
Caffeine is well known for its complex pharmacological actions, in part reflecting the multiple molecular targets of caffeine. The adenosine receptors are the primary extracellular targets of caffeine. Since caffeine has similar affinity for several adenosine receptors, it has been difficult to determine which receptor subtypes mediate caffeine's effects using pharmacological tools. The develop...
SUMMARY The mechanisms underlying the etiology and pathophysiology of anxiety disorders - the most prevalent class of mental disorders - remain unclear. Over the last 30 years investigators have used the animal model of conditioned fear stress (CFS) to investigate the brain structures and neurotransmitter systems involved in aversive emotional learning and memory. Recent studies have focused on...
abstract nowadays, industries cannot play a crucial role in national and international competitions. the tourism industry is no exception. tourism industry development as the most important economic sector and income generation is one of the key challenges of economic development in the world. therefore, countries were successful that take advantage of the capabilities of tourism sector using ...
the main purpose of this research was to:1.develop a coking model for thermal cracking of naphtha.2.study coke inhibition methods using different coke inhibitors.developing a coking model in naphtha cracking reactors requires a suitable model of the thermal cracking reactor based on a reliable kinetic model.to obtain reliable results all these models shall be solved simultaneously.for this pu...
Dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and Hodgkin’s disease. It requires initial activation in liver through an N-demethylationreaction. The active metabolite prevents the progress of disease via alkylation of guanine bases in DNA strands. In order to investigate the importance of imidazole ring and its dynamictautomerization in ant...
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