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Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due in part to the biochemical complexity of mitochondrial respiration and the fact that two genomes, one mitochondrial and one nuclear, encode the components of the respiratory chain. Because of the large number of genes involved, attempts to classify mitochondrial RCD incorporate ...

The Clp/Hsp100 molecular chaperones are unusual in their ability to tease apart protein aggregates and complexes. Recent results make a good case that these chaperones bind substrates via PDZ-like domains; this may reflect a general strategy for manipulating the] assembly state of substrate proteins.

Molecular genetics to genomic medicine practice: at the heart of value-based delivery of healthcare Charis Eng Genomic Medicine Institute, Lerner Research Institute, Taussig Cancer Institute and Stanley Shalom Zielony Institute of Nursing Research, Cleveland Clinic, Cleveland, OH 44195 Department of Genetics and Genome Sciences, CASE Comprehensive Cancer Center, Case Western Reserve University ...

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In the past years an increasing number of graphical user interfaces for Molecular Dynamics (MD) were presented and concomitantly, more and more Molecular Dynamics studies were published. With the easier application of MD software packages the field runs the risk however, of being pervaded with unreliable results. Therefore, possible benefits and caveats have to be carefully balanced. Here we ou...

Molecular Dynamic Studies of Viral-Protein Based Nano-Actuators A. Dubey1, C. Mavroidis2 ∗, and M. S. Tomassone3 ∗ 1Department of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, NJ, USA 2Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA 3Department of Chemical and Biochemical Engineering, Rutgers, The State Universit...