نتایج جستجو برای: mody
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ZarzÄ dzanie Mediami » 2022 Tom 10, Numer 2 Recenzja monografii MichaÅa Wójciaka pt. Metafory mody. markÄ autorskÄ w kontekÅcie przemian rynkowych – perspektywa projektantów A
It is often difficult to identify maturity-onset diabetes of the young (MODY) in pediatric patients close onset. Hence, misdiagnosis and unnecessary insulin treatment are still common.
The insulin gene mutation c.137G>A (R46Q), which changes an arginine at the B22 position of the mature hormone to glutamine, causes the monogenic diabetes variant maturity-onset diabetes of the young (MODY). In MODY patients, this mutation is heterozygous, and both mutant and wild-type (WT) human insulin are produced simultaneously. However, the patients often depend on administration of exogen...
IT IS SUPPOSED that every gene in the body has a constellation of controlling elements serving as binding sites for transcription factors working coordinately in a tissue-specific, temporal, and/or developmental fashion. These DNA elements are bound by a community of protein factors organized around transcription start sites to regulate the relative activities and levels of expression of genes ...
OBJECTIVE In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A-maturity onset diabetes of the young (HNF1A-MODY). Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the rege...
HNF4α (hepatocyte nuclear factor 4α) is a culprit gene product for a monogenic and dominantly inherited form of diabetes, referred to as MODY (maturity onset diabetes of the young). As a member of the NR (nuclear receptor) superfamily, HNF4α recruits transcriptional co-activators such as SRC-1α (steroid receptor co-activator-1α) and PGC-1α (peroxisome-proliferator-activated receptor γ co-activa...
AMAÇ: Glukokinaz (GCK) gen mutasyonu pozitif olan Genç Erişkin Dönemde Başlayan Diyabet (Maturity Onset Diabetes of Young - MODY) tanısı alan olgularla sağlıklı bireylerin koroid tabakası kalınlıklarının karşılaştırılması amaçlandı.GEREÇ VE YÖNTEM: MODY GCK bakılarak doğrulanmış ama diyabetik retinopatisi olmayan 30 hasta (MODY grubu) ve sağlıklı kişi (kontrol çalışmaya dahil edildi. Kontrol gr...
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