Purpose The purpose of this paper is to evaluate the impact on stress and work-related outcomes an app-delivered mindfulness-based program (MBP; Headspace®) offered employees in a UK higher education (HE) institution. Design/methodology/approach Using randomized waitlist control trial design, participants were randomly allocated be (MBP) immediately for 2 months or after waiting list period (WL...

Three custom synthesized myelin basic protein (MBP) peptides, bovine peptide 79-88, human peptide 80-89, and human peptide 82-91, were used to produce four murine monoclonal antibodies (MAb) that were selected on the basis of reaction in a solid phase radioimmunoassay (SRIA) with human MBP. The MAb were compared with respect to antigen specificity against intact MBP and 10 overlapping MBP pepti...

The pathogenesis of multiple sclerosis involves a breakdown in T cell tolerance to myelin proteins like myelin basic protein (MBP). Most MBP-specific T cells are eliminated by central tolerance in adult mice, however, the developmentally regulated expression of MBP allows MBP-specific thymocytes in young mice to escape negative selection. It is not known how these T cells that encounter MBP for...

Abstract Pasta, a staple food worldwide consumed, was fortified with maqui ( Aristotelia chilensis ) berry powder (MBP) and the effect of MBP inclusion evaluated concerning technological, nutritional, sensory properties. Fresh pasta samples were formulated by replacing 0, 7.5, 15 g 100 −1 durum wheat semolina MBP. The did not affect moisture content, but water activity decreased in samples, whi...

In back-propagation (Rumelhart et al, 1985) connection weights are used to both compute node activations and error gradients for hidden units. Grossberg (1987) has argued that the dual use of the same synaptic connections (“weight transport”) constitutes a bidirectional flow of information through synapses, which is biologically implausable. In this paper we formally and empirically demonstrate...

MBPConflate is proof-of-concept software developed to aid in conflation research. The program implements a powerful algorithm for automatic multi-source image conflation that utilizes new Algebraic Systems-based similarity metrics during the feature comparison process. One benefit of integrating Algebraic Systems into the feature comparison process is that more global shape properties can be di...

Vaccination with synthetic TCR peptides from the BV5S2 complementarity-determining region 2 (CDR2) can boost significantly the frequency of circulating CD4+ peptide-specific Th2 cells in multiple sclerosis (MS) patients, with an associated decrease in the frequency of myelin basic protein (MBP)-reactive Th1 cells and possible clinical benefit. To evaluate the immunogenicity of CDR2 vs other reg...

In vivo adoptive transfer of CD4+ T helper cell type 1 clones reactive with autologous myelin basic protein (MBP) may initiate an inflammatory demyelinating disease of the central nervous system called experimental autoimmune encephalomyelitis. Although MBP is also a component of peripheral nervous system (PNS) myelin, previous studies have failed to demonstrate inflammation in the PNS induced ...

We studied a device that is commonly used for amplitude demodulation of respiratory muscle electromyograms (EMG). This device contains a rectifier and a low-pass filter called a modified third-order Paynter filter. We characterized this filter and found that it has good transient characteristics that suit its task as an EMG demodulator, but it has poor high-frequency attenuation that passes int...

Autoreactive T cells of CD4 and CD8 subsets recognizing myelin basic protein (MBP), a candidate myelin autoantigen, are thought to contribute to and play distinct roles in the pathogenesis of multiple sclerosis (MS). In this study we identified four MBP-derived peptides that had high binding affinity to HLA-A2 and HLA-A24 and characterized the CD8(+) T cell responses and their functional proper...