Stereocontrolled Mn-mediated radical addition of alkyl iodides to chiral N-acylhydrazones enables strategic C-C bond disconnection of chiral amines. This strategy was examined in the context of a total synthesis of quinine, generating new findings of functional group compatibility leading to a revised strategy. Completion of a formal synthesis of quinine is presented, validating the application...

Manganese (Mn) is found in three major biologically-relevant oxidation states Mn(II), Mn(III) and Mn(IV), and it is an essential trace metal that is involved for several pathway, in the normal cell function and metabolism. However, since XIX century, the Mn is well known as neuro (toxic) agent, during acute and chronic exposure for air, water or aliments containing either highor low-level conce...

The occurrence of manganese (Mn) deficiency in cereal crops has increased in recent years. This coincides with increasing phosphorus (P) status of many soils due to application of high levels of animal manure and P-fertilizers. In order to test the hypothesis that elevated P my lead to Mn deficiency we have here conducted a series of hydroponics and soil experiments examining how the P supply a...

In order to propose an optimal analytical procedure specific ferromanganese (Fe–Mn) oxides, we investigated different modes of data acquisition using inductively coupled plasma mass spectrometry (ICP-MS). The results trace element and Rare Earth Element (REE) determination in eight Fe–Mn nodules crusts (FeMn-1, GSMC-1, GSMC-2, GSMC-3, GSPN-2, GSPN-3, NOD-A-1 NOD-P-1) are presented here. involve...