The microphthalmia with linear skin defects syndrome (MLS) is an X-linked dominant disorder with male lethality. In the majority of the patients reported, the MLS syndrome is caused by segmental monosomy of the Xp22.3 region. To date, five male patients with MLS and 46,XX karyotype ("XX males") have been described. Here we report on the first male case with MLS and an XY complement. The patient...

Myxoid/round-cell liposarcoma (MLS/RCLS) is characterized by either the fusion gene FUS-DDIT3 or the less commonly occurring EWSR1-DDIT3 and most cases carry few or no additional cytogenetic changes. There are conflicting reports concerning the status and role of TP53 in MLS/RCLS. Here we analysed four MLS/RCLS derived cell lines for TP53 mutations, expression and function. Three SV40 transform...

T cell responses to the product of the minor lymphocyte stimulatory locus Mls-1a involve the selective use of TCR V beta domains (especially V beta 6 and V beta 8.1) and are generally considered to be restricted to the CD4+ mature subset. We show here that CD8+ (presumably MHC class I-restricted) T cells bearing V beta 6 or V beta 8.1 also respond preferentially to Mls-1a determinants either in...

Introduction: The H spectra of certain tumor cells, in vivo tumors and biopsies, show an intense resonance in the 1.26-1.30 ppm area that has been usually assigned to NMR visible mobile lipids (MLs) . The presence of large ML signal seems to correlate with necrotic areas in the tumors 3 and the non-invasive detection of necrosis would suggest a high grade of malignancy in untreated tumors or co...

We consider the problem of static transmissionpower assignment for lifetime maximization of a wireless sensor network with stationary nodes operating in a datagathering scenario. Using a graph-theoretic approach, we propose two distributed algorithms, MLS and BSPAN, that construct spanning trees with minimum maximum (minmax) edge cost. MLS is based on computation of minmaxcost paths from a refe...

numerical solutions obtained by the meshless local petrov–galerkin (mlpg) method are presented for two-dimensional steady-state heat conduction problems. the mlpg method is a truly meshless approach, and neither the nodal connectivity nor the background mesh is required for solving the initial-boundary-value problem. the penalty method is adopted to efficiently enforce the essential boundary co...

The objective of this study was to identify the differences in histopathological distribution and clinical features of mediastinal lesions (MLs) across the age spectrum in Chinese series of patients and to compare with the available literature. A total of 409 cases of MLs, including 137 pediatric and 272 adult patients from a single institution, was reviewed and categorized into groups accordin...

Two-way group voice communications, otherwise known as teleconferencing are common in commercial and defense networks. One of the main features of military teleconferences is the need to provide means to enforce the Multilevel Security (MLS) model. In this paper we propose an architecture and protocols facilitating MLS conferences over Public Switched Telephone Network (PSTN). We develop protoc...

This article presents an extension to a Multi-Level Secure (MLS) data model that requires the classification of data and users into multiple security levels. In MLS systems, cover stories allow information provided to users at lower security levels to differ from information provided to users at higher security levels. Previous versions of the MLS model did not permit cover stories for key attr...

With sensors and mobile devices becoming ubiquitous, situation monitoring applications are becoming a reality. Data Stream Management Systems (DSMSs) have been proposed to address the data processing needs of such applications that require collection of high-speed data, computing results on-the-fly, and taking actions in real-time. Although a lot of work appears in the area of DSMS, not much ha...