purpose: to compare the success rate of mitomycin-c versus bevacizumab for prevention of bleb failure following phacotrabeculectomy. method: in this study 74 eyes of 69 patients with uncontrolled iop, progressive visual field loss and cataract were randomized in two groups. in the first group, after conjunctival peritomy at the sclera flap site, sponge pats soaked in mitomycin c with concentrat...

purpose: to compare the efficacy and safety of topical mitomycin-c (mmc) drops versus subconjunctival 5-fluourouracil (5-fu) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (pt+pciol). methods: in a comparative study, 37 eyes of 37 patients with impending early bleb failu...

A patient with pseudomyxoma peritonei underwent Hyperthermal Intraperitoneal Chemotherapy (HIPEC) with Mitomycin C after which she developed thrombotic microangiopathy. This syndrome mimicked possible surgical complications. Treatment with plasma exchange resolved the syndrome and the patient recovered completely. This is the first description of thrombotic microangiopathy early after a single ...

Choanal stenosis has recently been recognized as a late complication of radiation therapy for nasopharyngeal carcinoma. The management of velopharyngeal stenosis is challenging with high risk of restenosis. We report a case of velopharyngeal stenosis post-radiotherapy and illustrated the use of mitomycin-C to prevent restenosis. Mitomycin-C application has being shown useful adjunct to surgical...

OBJECTIVE To determine the incidence of focal, late-onset, conjunctival bleb leaks after glaucoma filtering surgery. DESIGN Prospective, cross-sectional analysis. SETTING Tertiary care outpatient referral center. PATIENTS Consecutive patients who underwent glaucoma filtering surgery prior to June 1996 presenting for evaluation from September 2,1996, through November 15,1996. Five hundred ...

Objective: To determine the effect of intravitreally administered bevacizumab, alone or as adjunct to mitomycin-C, after trabeculectomy on bleb survival and histology in rabbit eyes. Methods: An experimental, interventional, comparative, animal study consisting of 16 rabbit eyes underwent trabeculectomy, 8 of which were enhanced with intra-operative mitomycin-C. Eyes were randomized to receive ...

The antitumor antibiotic mitomycin C is shown to form a covalent complex with calf thymus DNA under anaerobic conditions in the presence of either NADPH cytochrome c reductase/NADPH, xanthine oxidase/NADH, or the chemical reducing system H2/PtO2. Digestion of the complex with DNase I/snake venom diesterase/alkaline phosphatase yields a single mitomycin deoxyguanosine adduct as the major DNA alk...

This nonblinded, multicenter, randomized phase III study compares the median time to progression (primary endpoint), response rate, and quality of life, safety, and survival of docetaxel (Taxotere) vs mitomycin (Mutamycin) plus vinblastine (Velban) in patients with metastatic breast cancer in whom previous anthracycline-containing chemotherapy has failed. Patients were randomized to receive an ...

AIM To study the efficacy and safety of amniotic membrane graft as an adjunctive therapy after removal of primary pterygium, and to compare the clinical outcome with conjunctival autograft and topical mitomycin C. METHODS 80 eyes of 71 patients with primary pterygia were treated with excision followed by amniotic membrane graft. The result was compared retrospectively with 56 eyes of 50 patie...

Many cancer therapeutic agents have been used for experimental and clinical purposes. It has been established that generally such agents are toxic to embryos with highly mitotic activities as well as other rapidly growing or proliferating tissues. The teratogenicity of these agents has been shown in rodents (Reviewed by Nishimura, '64; Karnof sky, '65; Dagg, '66). Murphy et at. ('58) found that...