نتایج جستجو برای: mitochondrial cytopathy

تعداد نتایج: 132432  

 Background and purpose: Resveratrol (RSV) is a naturally polyphenolic compound found in grapes and other plant sources. It has potent free radical scavenger and antioxidative properties.The aim of this study was to evaluate the protective effect of resveratrol against Perfluorooctanoic acid (PFOA) induced mitochondrial toxicity in isolated liver mitochondria. Materials and methods: Mitochondr...

Journal: :iranian journal of child neurology 0
elham rahimian radiologist, andisheh badie rayan research institute and haghighat medical imaging center, tehran, iran majid tahsini biomedical engineer, andisheh badie rayan institute and haghighat medical imaging center seyed hassan tonekaboni 3. pediatric neurology research center, shahid behesti university of medical sciences, tehran, iran 4. department of pediatric neurology, pediatric neurology center of excellence, mofid children hospital, faculty of medicine, shahid behesti university of medical sciences, tehran, iran parvaneh karimzadeh 3. pediatric neurology research center, shahid behesti university of medical sciences, tehran, iran 4. department of pediatric neurology, pediatric neurology center of excellence, mofid children hospital, faculty of medicine, shahid behesti university of medical sciences, tehran, iran

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ژورنال: :genetics in the 3rd millennium 0
سمیرا شیبانی نیا samira sheybaninia پریسا آزادفر parisa azadfar لیلا اکبری leila akbari فرهاد عصارزادگان farhad assarzadegan مسعود هوشمند massoud houshmand بخش ژنتیک پزشکی، پژوهشگاه ملی مهندسی ژنتیک، تهران، ایران

بیماری آلزایمر مهمترین شکل زوال عقل در افراد مسن است که تاثیر متقابل ژن ها و محیط در شکل گیری آن نقش دارد. نقش جهش های میتوکندریایی در بیماری های مختلف فساد عصبی اثبات شده که برخی از این جهش ها به ظن قوی سبب بیماری آلزایمر در الگوی وراثت مادری آن هستند که به صورت غیر مندلی به ارث می رسد. همه ژن های trna میتوکندریایی در 24 بیمار و 50 نمونه سالم به عنوان کنترل با روش توالی یابی مورد آزمایش قرار گ...

Journal: :journal of research in medical sciences 0
reza sharafati?chaleshtori hedayatollah shirzad mahmoud rafieian kopaei amin soltani

mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synthase activity, increase in nitric oxide production, and impair in electron transport system and/or...

Journal: :iranian journal of toxicology 0
جلال پور احمد jalal pourahmad faculty of pharmacy and pharmaceutical research center, shahid beheshti medical university, tehran, iran فرحناز تنباکوسازان farahnaz tanbakosazan faculty of pharmacy and pharmaceutical research center, shahid beheshti medical university, tehran, iran منیره قشنگ monireh ghashang faculty of pharmacy and pharmaceutical research center, shahid beheshti medical university, tehran, iran

introduction: recently depleted uranium is being widely used as anti-armour ammunition and at very high temperature, results in information of an aerosol of very small uranium oxide particles, which may be inhaled. it is alleged that these particles represent a new battlefield hazard because of the chemical toxicology and/or radioactivity. method & materials: male wistar strain albino rats were...

Journal: :iranian journal of child neurology 0
bita shalbafan neurologist, specialist on neurometabolic disorders, social security organization, tehran, iran

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Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...

Background and purpose: Curcumin is a natural polyphenolic compound in turmeric (Curcuma longa). Curcumin has potent free radical scavenger and antioxidant properties that could significantly reduce oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to valproate sodium induced tissue damage. This study investigated the protective effects of curcumin against valproate so...

Journal: :iranian journal of public health 0
sa alemohammad dd farhud m hooshmand m sanati p derakhshandeh-peykar sj imam

a 9 bp deletion between cytochrome oxidase subunit ii and trna lys genes in mitochondrial dna, has proven to be an extremely informative marker for tracing population history. using the pcr-page and pcr-sscp techniques in this study, 152 dna samples collected from iranian populations were screened for the 9 bp deletion. no deletion was observed. a length polymorphism, most probably a 9 bp tripl...

Journal: :progress in biological sciences 2011
hamed vahdati nasab

mitochondrial deoxyribonucleic acid (mtdna) polymorphisms were examinedin bone samples of individuals buried inan early neolithic (c. 5800–4900 bce) hunter-gatherer cemetery, shamanka ii, located atthe southwestern tip of lake baikal, siberia. the mainobjective was to compare the mtdna polymorphisms observed at shamanka ii to those previously reportedfrom the lokomotiv (early neolithic) and ust...

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