MicroRNAs (miRNAs) are regulators of gene expression in plants and animals. The biogenesis of miRNAs is precisely controlled to secure normal development of organisms. Here we report that TOUGH (TGH) is a component of the DCL1-HYL1-SERRATE complex that processes primary transcripts of miRNAs [i.e., primary miRNAs (pri-miRNAs)] into miRNAs in Arabidopsis. Lack of TGH impairs multiple DCL activit...

MicroRNAs (miRNAs) are a specialized group of small RNAs (sRNAs) that regulate gene expression in plants at both transcriptional and post-transcriptional levels. Numerous families miRNA target genes involved regulating plant immunity. In this study, we studied the role miRNAs defensive response against fungal pathogen, Fusarium oxysporum f. sp. lycopersici, which causes wilt disease tomatoes. F...

microRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Multiple studies report that miRNAs are involved in homeostatic maintenance and that aberrant expression of miRNAs is often observed in various types of diseases, including cancer. In cancer biology, miRNAs ...

MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical posttranscriptional regulators of gene expression by promoting mRNA degradation and translational inhibition. Placenta expresses many ubiquitous as well as specific miRNAs. These miRNAs regulate trophoblast cell differentiation, proliferation, apoptosis, invasion/migration, and angiogenesis, suggesting that miRNAs play imp...

The miR169 family is one of the largest families known miRNAs, which performs important functions in plant growth, development, and responses to biotic/abiotic stresses. However, its response abiotic stresses are still unclear poplar. In present study, a total 33 precursor MIR169s were identified from poplar divided into 3 groups by evolutionary analysis multiple sequence alignment, with member...

BackgroundMyocardial fibrosis is a hallmark of the failing heart, contributing to most common causes deaths worldwide. Several microRNAs (miRNAs, miRs) controlling cardiac were identified in recent years; however, more global approach identify miRNAs involved missing.Methods and resultsFunctional miRNA mimic library screens applied human fibroblasts (HCFs) annotated inducing proliferation. In p...

MicroRNAs (miRNAs) are small regulatory molecules that involved in posttranscriptional modifications. These noncoding RNAs usually ferried by extracellular carriers such as exosomes or other protein and lipid inside a range of body fluids including plasma urine. Due to their ability withstand harsh external conditions, exosomal miRNAs possess enormous potential noninvasive disease biomarkers fo...

MicroRNA (miRNA) is a class of small non-coding RNAs that are encoded in genomes. The discovery of miRNAs is one of the biggest breakthrough in molecular biology in the last decade. MiRNAs have been viewed by many to form an extra regulatory layer for gene expression. However, the functional role of miRNAs in the cell and the evolutionary role of miRNAs in species are still not well understood....